Late onset of nivolumab-induced severe gastroduodenitis and cholangitis in a patient with stage IV melanoma

被引：22

作者：

Calugareanu, Andreea ^{[1
]}

Rompteaux, Pierre ^{[2
]}

Bohelay, Gerome ^{[2
,3
]}

Goldfarb, Lucas ^{[4
]}

Barrau, Vincent ^{[5
]}

Cucherousset, Nahla ^{[6
]}

Heidelberger, Valentine ^{[1
]}

Nault, Jean-Charles ^{[7
,8
]}

Ziol, Marianne ^{[9
,10
]}

Caux, Frederic ^{[1
,2
]}

Maubec, Eve ^{[1
,2
]}

机构：

[1] Hop Univ Paris Seine St Denis, Avicenne Hosp, AP HP, Dermatol Dept, Bobigny, France

[2] Hop Univ Paris Seine St Denis, Avicenne Hosp, AP HP, Hepatogastroenterol Dept, Bobigny, France

[3] Paris 13 Univ, Bobigny, France

[4] Hop Univ Paris Seine St Denis, Avicenne Hosp, AP HP, Nucl Med Dept, Bobigny, France

[5] Ctr Cardiol Nord, Radiol Dept, St Denis, Reunion, France

[6] Hop Univ Paris Seine St Denis, Avicenne Hosp, AP HP, Pathol Dept, Bobigny, France

[7] Hop Univ Paris Seine St Denis, Jean Verdier Hosp, AP HP, Hepatol Dept, Bondy, France

[8] Univ Paris 13, Univ Paris Diderot, Univ Paris Descartes,Labex Immunooncol, Genom Fonct Tumeurs Solides,Inserm,UMR 1162, Paris, France

[9] Hop Univ Paris Seine St Denis, Hop Jean Verdier, AP HP, Dept Pathol, Bondy, France

[10] Hop Univ Paris Seine St Denis, Hop Jean Verdier, AP HP, Ctr Biol Resources BB 0033 00027, Bondy, France

来源：

IMMUNOTHERAPY | 2019年 / 11卷 / 12期

关键词：

anti-PD-1; protein; cholangitis; duodenitis; gastritis; melanoma; nivolumab; PET-CT; IMMUNE; IPILIMUMAB; DIAGNOSIS;

D O I：

10.2217/imt-2019-0077

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antiprogramed cell death-1 protein agents represent a therapeutic approach based on stimulating the host's immune response through blockade of immune checkpoints, inhibitory pathways that dampen the physiological peripheral T-cell immune response and are essential for maintaining self-tolerance. We describe the late onset of severe gastroduodenitis and cholangitis in a nivolumab-treated, metastatic melanoma patient in complete remission. Positron-emission tomography with computed tomography scans showed diffuse fluorodeoxyglucose (FDG) uptake in the stomach preceding upper digestive tract symptoms. Hence, positron-emission tomography with computed tomography might as well be a useful tool for early diagnosis of subclinical gastric toxicity as recently shown for colitis. Furthermore, physicians must be aware and remain vigilant to antiprogramed cell death-1 protein-related digestive toxicity that may appear very late during treatment.

引用

页码：1005 / 1013

页数：9

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