Antiplasmodial activity of mono- and dimeric carbazoles

被引：36

作者：

Bringmann, G ^{[1
]}

Ledermann, A

Holenz, J

Kao, MT

Busse, U

Wu, HG

Francois, G

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] BASF AG, APE, EF, D-6703 Limburgerhof, Germany

[3] BASF Taiwan Ltd, Taipei, Taiwan

[4] Prins Leopold Inst Trop Geneeskunde, Antwerp, Belgium

来源：

PLANTA MEDICA | 1998年 / 64卷 / 01期

关键词：

Murraya euchrestifolia; Rutaceae; Carbazoles; Murraya alkaloids; murrayafoline A; bismurrayaquinone A; koenoline; antiplasmodial activity; Plasmodium falciparum; human malaria;

D O I：

10.1055/s-2006-957366

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A series of mono-and dimeric natural and structurally modified carbazoles has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 mu g/ml. It is distinctly more active than the as yet best natural compound, 1-hydroxy-3-methylcarbazole (4) (4).

引用

页码：54 / 57

页数：4

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