Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates

被引：168

作者：

Wang, Fen ^{[1
]}

Wang, He ^{[1
]}

Wang, Qiang ^{[1
]}

Yu, Songjie ^{[1
]}

Li, Xingwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 06期

关键词：

ONE-POT SYNTHESIS; BOND-FORMATION; COBALT(III)-CATALYZED ARYL; DIAZO-COMPOUNDS; AMIDATION; FUNCTIONALIZATION; AMINATION; ALKYNES; ACCESS; ARENES;

D O I：

10.1021/acs.orglett.6b00227

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.

引用

页码：1306 / 1309

页数：4

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