CDK-independent activation of estrogen receptor by cyclin D1

被引：602

作者：

Zwijsen, RML ^{[1
]}

Wientjens, E ^{[1
]}

Klompmaker, R ^{[1
]}

vanderSman, J ^{[1
]}

Bernards, R ^{[1
]}

Michalides, RJAM ^{[1
]}

机构：

[1] NETHERLANDS CANC INST,ANTONI VAN LEEUWENHOEK HUIS,DEPT MOL CARCINOGENESIS,NL-1066 CX AMSTERDAM,NETHERLANDS

来源：

CELL | 1997年 / 88卷 / 03期

关键词：

D O I：

10.1016/S0092-8674(00)81879-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Both cyclin D1 and estrogens have an essential role in regulating proliferation of breast epithelial cells. We show here a novel role for cyclin D1 in growth regulation of estrogen-responsive tissues by potentiating transcription of estrogen receptor-regulated genes. Cyclin D1 mediates this activation independent of complex formation to a CDK partner. Cyclin D1 activates estrogen receptor-mediated transcription in the absence of estrogen and enhances transcription in its presence. The activation of estrogen receptor by cyclin D1 is not inhibited by anti-estrogens. A direct physical binding of cyclin D1 to the hormone binding domain of the estrogen receptor results in an increased binding of the receptor to estrogen response element sequences, and upregulates estrogen receptor-mediated transcription. These results highlight a novel role for cyclin D1 as a CDK-independent activator of the estrogen receptor.

引用

页码：405 / 415

页数：11

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[1] MODULATION OF TRANSCRIPTIONAL ACTIVATION BY LIGAND-DEPENDENT PHOSPHORYLATION OF THE HUMAN ESTROGEN RECEPTOR-A/B REGION [J].