Synthetic CaSiO3 sol-gel powder and SPS ceramic derivatives: "In vivo" toxicity assessment

被引：27

作者：

Papynov, Evgeniy Konstantinovich ^{[1
,2
]}

Shichalin, Oleg Olegovich ^{[1
]}

Apanasevich, Vladimir Iosifovich ^{[3
]}

Afonin, Igor Sergeevich ^{[3
]}

Evdokimov, Ivan Olegovich ^{[2
]}

Mayorov, Vitaliy Yurievich ^{[1
]}

Portnyagin, Arseniy Sergeevich ^{[1
,2
]}

Agafonova, Irina Grigorievna ^{[4
]}

Skurikhina, Yulia Evgenievna ^{[3
]}

Medkov, Mikhael Azarievich ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Chem, Far Eastern Branch, 159 Prosp 100 Letiya Vladivostoka, Vladivostok 690022, Russia

[2] Far Eastern Fed Univ, 8 Suhanova St, Vladivostok 690091, Russia

[3] Pacific State Med Univ, 2 Ostryakov Aven, Vladivostok 690990, Russia

[4] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, 159 Prosp 100 Letiya Vladivostoka, Vladivostok 690022, Russia

来源：

PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL | 2019年 / 29卷 / 05期

基金：

俄罗斯科学基金会;

关键词：

Porous wollastonite; Biomaterials; Sol-gel synthesis; SPS; Toxicity; CALCIUM SILICATE; WOLLASTONITE; VITRO; BIOACTIVITY; SCAFFOLDS; DEGRADATION; FABRICATION; COMPOSITE; BEHAVIOR;

D O I：

10.1016/j.pnsc.2019.07.004

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The paper presents template strategy using siloxane-acrylate latex and its modified form to prepare nanostructured calcium silicate (wollastonite) containing nanosized gold and regular porosity. Optimal conditions for the annealing of silicate xerogel were outlined leading to nanoporous wollastonite with minimal porous defects (pore size corresponds to latex particles 150-200 nm). The fabrication of nanostructured wollastonite ceramics was suggested to use spark plasma sintering (SPS). The formation of porous ceramic framework (compressive strength similar to 120 MPa) via SPS consolidation of silicate xerogel (xonotlite) contained latex template (poreformer), a feature of the method for wollastonite template synthesis. The ceramic wollastonite samples have been implanted into ICR/CD1 mice to test the toxicity of the material "in vivo". The results are of great interest for the preparation of high-quality biomaterials for modern medicine using simple technological approaches and available raw materials.

引用

页码：569 / 575

页数：7

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