Potentiality of miniaturized techniques for the analysis of drugs of abuse

被引：9

作者：

Fanali, Chiara ^{[1
]}

D'Orazio, Giovanni ^{[2
]}

Gentili, Alessandra ^{[3
]}

Fanali, Salvatore ^{[4
]}

机构：

[1] Univ Campus Biomed Rome, Fac Sci, Via Alvaro del Portillo 21, I-00128 Rome, Italy

[2] CNR, Inst Biol Syst, Monterotondo, Italy

[3] Univ Roma La Sapienza, Dept Chem, Rome, Italy

[4] Univ Verona, Teaching Comm PhD Sch Nat Sci & Engn, Verona, Italy

来源：

ELECTROPHORESIS | 2022年 / 43卷 / 1-2期

关键词：

Capillary electrochromatography; Capillary electrophoresis; Capillary liquid chromatography; Drugs of abuse; Miniaturized techniques; NANO-LIQUID CHROMATOGRAPHY; SOLID-PHASE MICROEXTRACTION; CAPILLARY-ELECTROPHORESIS; CATHINONE DERIVATIVES; MASS-SPECTROMETRY; IN-LINE; SEPARATION; HAIR; ELECTROCHROMATOGRAPHY; CYCLODEXTRIN;

D O I：

10.1002/elps.202100150

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Capillary electromigration (CE) and liquid chromatographic techniques (CLC/nano-LC) are miniaturized techniques offering distinct advantages over conventional ones in the field of separation science. Among these, high efficiency, high chromatographic resolution, and use of minute volumes of both mobile phase and sample volumes are the most important. CE and CLC/nano-LC have been applied to the analysis of many compounds including peptides, proteins, drugs, enantiomers, ions, etc. Over the years, the methods described here have also been used for the analysis of compounds of clinical, forensic, and toxicological interest. In this review article, the main features of the mentioned techniques are summarized. Their potentiality for the analysis of drugs of abuse are discussed. Some selected applications in this field in the period of 2015-present are also reported.

引用

页码：190 / 200

页数：11

共 53 条

[1] On-site detection of fentanyl and its derivatives by field portable nano-liquid chromatography-electron lonization-mass spectrometry (nLC-EI-MS) [J].

Abonamah, Jocelyn V. ;

Eckenrode, Brian A. ;

Moini, Mehdi .

FORENSIC CHEMISTRY, 2019, 16

[2] Chiral separations of cathinone and amphetamine-derivatives: Comparative study between capillary electrochromatography, supercritical fluid chromatography and three liquid chromatographic modes [J].

Albals, Dima ;

Vander Heyden, Yvan ;

Schmid, Martin G. ;

Chankvetadze, Bezhan ;

Mangelings, Debby .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 121 :232-243

[3]

Aturki Z, 2015, LC GC N AM, V33, P786

[4] Recent trends in analytical methods and separation techniques for drugs of abuse in hair [J].

Baciu, T. ;

Borrull, F. ;

Aguilar, C. ;

Calull, M. .

ANALYTICA CHIMICA ACTA, 2015, 856 :1-26

[5] Enantioselective determination of cathinone derivatives in human hair by capillary electrophoresis combined in-line with solid-phase extraction [J].

Baciu, Tatiana ;

Borrull, Francesc ;

Calull, Marta ;

Aguilar, Carme .

ELECTROPHORESIS, 2016, 37 (17-18) :2352-2362

[6] High-throughput screening of cocaine, adulterants, and diluents in seized samples using capillary electrophoresis with capacitively coupled contactless conductivity detection [J].

Barreto, Diandra N. ;

Ribeiro, Michelle M. A. C. ;

Sudo, Joao T. C. ;

Richter, Eduardo M. ;

Munoz, Rodrigo A. A. ;

Silva, Sidnei G. .

TALANTA, 2020, 217

[7] Chiral analysis of methorphan in opiate-overdose related deaths by using capillary electrophoresis [J].

Bertaso, Anna ;

Musile, Giacomo ;

Gottardo, Rossella ;

Seri, Catia ;

Tagliaro, Franco .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2015, 1000 :130-135

[8] Dextromethorphan/levomethorphan issues in a case of opiate overdose [J].

Bortolotti, Federica ;

Bertaso, Anna ;

Gottardo, Rossella ;

Musile, Giacomo ;

Tagliaro, Franco .

DRUG TESTING AND ANALYSIS, 2013, 5 (9-10) :781-784

[9] In-line solid-phase extraction-capillary electrophoresis coupled with mass spectrometry for determination of drugs of abuse in human urine [J].

Botello, Igor ;

Borrull, Francesc ;

Calull, Marta ;

Aguilar, Carme ;

Somsen, Govert W. ;

de Jong, Gerhardus J. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 403 (03) :777-784

[10] Simultaneous determination of new psychoactive substances and illicit drugs in sewage: Potential of micro-liquid chromatography tandem mass spectrometry in wastewater-based epidemiology [J].

Celma, Alberto ;

Sancho, Juan, V ;

Salgueiro-Gonzalez, Noelia ;

Castiglioni, Sara ;

Zuccato, Ettore ;

Hernandez, Felix ;

Bijlsma, Lubertus .

JOURNAL OF CHROMATOGRAPHY A, 2019, 1602 :300-309

← 1 2 3 4 5 6 →