Recent Updates on the Association Between Alzheimer's Disease and Vascular Dementia

被引：42

作者：

Ashraf, Ghulam M. ^{[1
]}

Chibber, Sandesh ^{[2
]}

Mohammad ^{[3
]}

Zaidi, Syed K. ^{[4
]}

Tabrez, Shams ^{[1
]}

Ahmad, Ausaf ^{[5
]}

Shakil, Shazi ^{[6
,7
]}

Mushtaq, Gohar ^{[8
]}

Baeesa, Saleh S. ^{[9
]}

Kamal, Mohammad A. ^{[10
]}

机构：

[1] King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia

[2] Ahmedabad Univ, Inst Life Sci, Ahmadabad, Gujarat, India

[3] Indian Inst Technol, Dept Biosci & Bioenegineering BSBE, Mumbai, Maharashtra, India

[4] King Abdulaziz Univ, Ctr Excellence Genom Med Res, Jeddah 21413, Saudi Arabia

[5] Amity Univ Uttar Pradesh, Amity Inst Biotechnol, Lucknow, Uttar Pradesh, India

[6] King Abdulaziz Univ, KACST Technol Innovat Ctr Personalized Med, Jeddah 21413, Saudi Arabia

[7] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah 21413, Saudi Arabia

[8] King Abdulaziz Univ, Coll Sci, Dept Biochem, Jeddah 21413, Saudi Arabia

[9] King Abdulaziz Univ, Coll Med, Div Neurosurg, Jeddah 21413, Saudi Arabia

[10] Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia

来源：

MEDICINAL CHEMISTRY | 2016年 / 12卷 / 03期

关键词：

Alzheimer's disease; dementia; insulin resistance syndrome; nitric oxide; reactive oxygen species; therapy; vascular dementia; ENDOTHELIAL GROWTH-FACTOR; GOAT HEART GALECTIN-1; CELL-DEATH MECHANISMS; CEREBRAL-BLOOD-FLOW; NITRIC-OXIDE; APOLIPOPROTEIN-E; OXIDATIVE STRESS; AMYLOID-BETA; INSULIN-RESISTANCE; MOUSE MODEL;

D O I：

10.2174/1573406411666151030111820

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The two most common forms of dementia are Alzheimer's disease (AD) followed by vascular dementia (VaD), together accounting for a whopping 60-80% of total dementia cases worldwide. Even though these diseases are recognized as 'common', they still remain underdiagnosed. Recent research suggests that AD and VaD are closely intertwined. The symptoms of AD and VaD can be similar and the two conditions can occur simultaneously. A large number of patients diagnosed with AD have also been reported with VaD-caused brain damage. Moreover, both the diseases have been reported to have similar risk factors. The overlap between these diseases is important because the lifestyle changes and medications prescribed to curb one of these diseases may also help curb the other. In the present review, we present an inclusive outline of the parallelism between AD and VaD by exploring potential commonalities at the mechanistic and therapeutic levels.

引用

页码：226 / 237

页数：12

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