Glomerulonephritis after hematopoietic cell transplantation: IgA nephropathy with increased excretion of galactose-deficient IgA1

被引：12

作者：

Hu, Susie L. ^{[1
]}

Colvin, Gerald A. ^{[2
]}

Rifai, Abdalla ^{[3
]}

Suzuki, Hitoshi ^{[4
,7
]}

Novak, Jan ^{[4
]}

Esparza, Alfredo ^{[3
]}

Farooqi, Shahida ^{[8
]}

Julian, Bruce A. ^{[4
,5
,6
]}

机构：

[1] Brown Univ, Warren Alpert Med Sch, Div Kidney Dis & Hypertens, Dept Med, Providence, RI 02912 USA

[2] Brown Univ, Warren Alpert Med Sch, Div Hematol Oncol, Dept Med, Providence, RI 02912 USA

[3] Brown Univ, Warren Alpert Med Sch, Dept Pathol & Lab Med, Providence, RI 02912 USA

[4] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

[5] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[6] Univ Alabama Birmingham, Dept Surg, Birmingham, AL 35294 USA

[7] Juntendo Univ, Sch Med, Tokyo 113, Japan

[8] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2010年 / 25卷 / 05期

基金：

美国国家卫生研究院;

关键词：

bone marrow transplantation; galactose-deficient IgA1; hematopoietic cell transplantation; IgA nephropathy; NEPHROTIC SYNDROME; IMMUNE-COMPLEXES; DISEASE;

D O I：

10.1093/ndt/gfp693

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

We report the development of IgA nephropathy (IgAN) following full myeloablative allogeneic hematopoietic cell transplantation in two patients with human leukocyte antigen (HLA) matched sibling donors, unrelated to active or chronic graft-versus-host disease. Both recipients had elevated urinary levels of galactose-deficient IgA1, and one donor-recipient pair had elevated serum levels of galactose-deficient IgA1. We propose that IgAN developed after bone marrow transplantation due to a non-graft-versus-host-disease-related multi-hit process associated with glomerular deposition of galactose-deficient IgA1. These two cases provide unique insight into the kinetics of overproduction of galactose-deficient IgA1 and its glomerular deposition and consequential renal injury in IgAN.

引用

页码：1708 / 1713

页数：6

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