A convenient method for the synthesis of phosphatidylcholines

被引：0
|
作者：
Bragina, NA [1 ]
Kurochkina, EY [1 ]
Anikin, AV [1 ]
Chupin, VV [1 ]
机构：
[1] Lomonosov Acad Fine Chem Technol, Moscow 117571, Russia
来源：
BIOORGANICHESKAYA KHIMIYA | 1998年 / 24卷 / 02期
关键词：
deuterium-labeled lipids; phosphatidylcholine; phosphorylation; choline tetraphenylborate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A convenient method for the preparation of phosphatidylcholines is proposed, which is based upon phosphorylation of diglycerides with phosphorus oxychloride followed by a reaction of the resulting dichlorophosphates with choline tetraphenylborates. This requires no isolation of intermediates and affords phosphatidylcholines with >60% yields. By its use, two novel ester and ether phosphatidylcholines with deuterium labels in the hydrophilic moiety, rac-1,2-dihexadecylglycero-3-phospho(H-2(13))choline and rac-1,2-dipalmitoylglycero-3-phospho(H-2(13))choline, were synthesized.
引用
收藏
页码：147 / 150
页数：4
相关论文
共 50 条
  • [1] IMPROVED METHOD FOR THE SYNTHESIS OF PHOSPHATIDYLCHOLINES
    HARBISON, GS
    GRIFFIN, RG
    JOURNAL OF LIPID RESEARCH, 1984, 25 (10) : 1140 - 1142
  • [2] A Convenient Method for the Synthesis of Aminomethylmonoalkylphosphinate
    Ding Derong
    Yan Guang
    CHINESE JOURNAL OF CHEMISTRY, 2012, 30 (08) : 1906 - 1908
  • [3] CONVENIENT METHOD OF ALKYLIDENEDIISOCYANATE SYNTHESIS
    VOVK, MV
    ZHURNAL OBSHCHEI KHIMII, 1992, 62 (03): : 713 - 714
  • [4] A CONVENIENT METHOD FOR THE SYNTHESIS OF KAEMPFEROL
    ICHIKAWA, M
    PAMUKCU, AM
    BRYAN, GT
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1982, 14 (03) : 183 - 187
  • [5] Convenient method for the synthesis of cinnamaldehyde
    Pan, Yi
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
  • [6] A convenient method for the synthesis of roflumilast
    Lin, Yan
    Huang, Peijun
    Liu, Shuai
    Sima, Lifeng
    Chen, Ligong
    Wang, Donghua
    RESEARCH ON CHEMICAL INTERMEDIATES, 2013, 39 (05) : 2107 - 2113
  • [7] A convenient method for the synthesis of roflumilast
    Yan Lin
    Peijun Huang
    Shuai Liu
    Lifeng Sima
    Ligong Chen
    Donghua Wang
    Research on Chemical Intermediates, 2013, 39 : 2107 - 2113
  • [8] CONVENIENT METHOD FOR SYNTHESIS OF HYDROXYMETHYLCARBAMATES
    FAHMY, MAH
    FUKUTO, TR
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1972, 20 (01) : 168 - &
  • [9] CONVENIENT METHOD OF HALOHYDRINE SYNTHESIS
    SOSNOVSKII, GM
    ASTAPOVICH, IV
    ZHURNAL ORGANICHESKOI KHIMII, 1990, 26 (04): : 911 - 912
  • [10] A convenient method of isoflavonone synthesis
    Aitmambetov A.
    Tlegenov R.T.
    Tokhtybaeva A.M.
    Russian Journal of Bioorganic Chemistry, 2006, 32 (4) : 400 - 401
12345