Hypoxia-inducible factors, stem cells, and cancer

被引：934
作者：
Keith, Brian
Simon, M. Celeste
机构：
[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Canc Biol, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
[4] Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA
来源：
CELL | 2007年 / 129卷 / 03期
关键词：
D O I：
10.1016/j.cell.2007.04.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regions of severe oxygen deprivation (hypoxia) arise in tumors due to rapid cell division and aberrant blood vessel formation. The hypoxia-inducible factors (HIFs) mediate transcriptional responses to localized hypoxia in normal tissues and in cancers and can promote tumor progression by altering cellular metabolism and stimulating angiogenesis. Recently, HIFs have been shown to activate specific signaling pathways such as Notch and the expression of transcription factors such as Oct4 that control stem cell self renewal and multipotency. As many cancers are thought to develop from a small number of transformed, self-renewing, and multipotent "cancer stem cells," these results suggest new roles for HIFs in tumor progression.
引用
收藏
页码：465 / 472
页数：8
相关论文
共 56 条
  • [31] Asymmetric and symmetric stem-cell divisions in development and cancer
    Morrison, Sean J.
    Kimble, Judith
    [J]. NATURE, 2006, 441 (7097) : 1068 - 1074
  • [32] Transient notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
    Morrison, SJ
    Perez, SE
    Qiao, Z
    Verdi, JM
    Hicks, C
    Weinmaster, G
    Anderson, DJ
    [J]. CELL, 2000, 101 (05) : 499 - 510
  • [33] Morrison SJ, 2000, J NEUROSCI, V20, P7370
  • [34] Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT)
    Nishi, H
    Nakada, T
    Kyo, S
    Inoue, M
    Shay, JW
    Isaka, K
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (13) : 6076 - 6083
  • [35] Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    Niwa, H
    Miyazaki, J
    Smith, AG
    [J]. NATURE GENETICS, 2000, 24 (04) : 372 - 376
  • [36] The stem cell niche: theme and variations
    Ohlstein, B
    Kai, T
    Decotto, E
    Spradling, A
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2004, 16 (06) : 693 - 699
  • [37] The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    Ohlstein, B
    Spradling, A
    [J]. NATURE, 2006, 439 (7075) : 470 - 474
  • [38] T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling
    Pear, WS
    Aster, JC
    [J]. CURRENT OPINION IN HEMATOLOGY, 2004, 11 (06) : 426 - 433
  • [39] Hypoxia signalling in cancer and approaches to enforce tumour regression
    Pouyssegur, Jacques
    Dayan, Frederic
    Mazure, Nathalie M.
    [J]. NATURE, 2006, 441 (7092) : 437 - 443
  • [40] Hypoxia-inducible factor and the development of stem cells of the cardiovascular system
    Ramírez-Bergeron, DL
    Simon, MC
    [J]. STEM CELLS, 2001, 19 (04) : 279 - 286
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