Hypoxia-inducible factors, stem cells, and cancer

被引：949

作者：

Keith, Brian

Simon, M. Celeste

机构：

[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Canc Biol, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[4] Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

来源：

CELL | 2007年 / 129卷 / 03期

关键词：

D O I：

10.1016/j.cell.2007.04.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regions of severe oxygen deprivation (hypoxia) arise in tumors due to rapid cell division and aberrant blood vessel formation. The hypoxia-inducible factors (HIFs) mediate transcriptional responses to localized hypoxia in normal tissues and in cancers and can promote tumor progression by altering cellular metabolism and stimulating angiogenesis. Recently, HIFs have been shown to activate specific signaling pathways such as Notch and the expression of transcription factors such as Oct4 that control stem cell self renewal and multipotency. As many cancers are thought to develop from a small number of transformed, self-renewing, and multipotent "cancer stem cells," these results suggest new roles for HIFs in tumor progression.

引用

页码：465 / 472

页数：8

共 56 条

[21] HIF-1α induces cell cycle arrest by functionally counteracting Myc [J].

Koshiji, M ;

Kageyama, Y ;

Pete, EA ;

Horikawa, I ;

Barrett, JC ;

Huang, LE .

EMBO JOURNAL, 2004, 23 (09) :1949-1956

[22] The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme [J].

Krishnamurthy, P ;

Ross, DD ;

Nakanishi, T ;

Bailey-Dell, K ;

Zhou, S ;

Mercer, KE ;

Sarkadi, B ;

Sorrentino, BP ;

Schuetz, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (23) :24218-24225

[23] Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9 [J].

Krivtsov, Andrei V. ;

Twomey, David ;

Feng, Zhaohui ;

Stubbs, Matthew C. ;

Wang, Yingzi ;

Faber, Joerg ;

Levine, Jason E. ;

Wang, Jing ;

Hahn, William C. ;

Gilliland, D. Gary ;

Golub, Todd R. ;

Armstrong, Scott A. .

NATURE, 2006, 442 (7104) :818-822

[24] Control of developmental regulator's by polycomb in human embryonic stem cells [J].

Lee, TI ;

Jenner, RG ;

Boyer, LA ;

Guenther, MG ;

Levine, SS ;

Kumar, RM ;

Chevalier, B ;

Johnstone, SE ;

Cole, MF ;

Isono, K ;

Koseki, H ;

Fuchikami, T ;

Abe, K ;

Murray, HL ;

Zucker, JP ;

Yuan, BB ;

Bell, GW ;

Herbolsheimer, E ;

Hannett, NM ;

Sun, KM ;

Odom, DT ;

Otte, AP ;

Volkert, TL ;

Bartel, DP ;

Melton, DA ;

Gifford, DK ;

Jaenisch, R ;

Young, RA .

CELL, 2006, 125 (02) :301-313

[25] The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells [J].

Loh, YH ;

Wu, Q ;

Chew, JL ;

Vega, VB ;

Zhang, WW ;

Chen, X ;

Bourque, G ;

George, J ;

Leong, B ;

Liu, J ;

Wong, KY ;

Sung, KW ;

Lee, CWH ;

Zhao, XD ;

Chiu, KP ;

Lipovich, L ;

Kuznetsov, VA ;

Robson, P ;

Stanton, LW ;

Wei, CL ;

Ruan, YJ ;

Lim, B ;

Ng, HH .

NATURE GENETICS, 2006, 38 (04) :431-440

[26] Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation [J].

Mancini, SJC ;

Mantei, N ;

Dumortier, A ;

Suter, U ;

MacDonald, HR ;

Radtke, F .

BLOOD, 2005, 105 (06) :2340-2342

[27] Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth [J].

Maxwell, PH ;

Dachs, GU ;

Gleadle, JM ;

Nicholls, LG ;

Harris, AL ;

Stratford, IJ ;

Hankinson, O ;

Pugh, CW ;

Ratcliffe, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (15) :8104-8109

[28] Transforming growth factor β1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression [J].

McMahon, Stephanie ;

Charbonneau, Martine ;

Grandmont, Sebastien ;

Richard, Darren E. ;

Dubois, Claire M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (34) :24171-24181

[29] Neural stem cells in mammalian development [J].

Merkle, Florian T. ;

Alvarez-Buylla, Arturo .

CURRENT OPINION IN CELL BIOLOGY, 2006, 18 (06) :704-709

[30] Dynamics of chronic myeloid leukaemia [J].

Michor, F ;

Hughes, TP ;

Iwasa, Y ;

Branford, S ;

Shah, NP ;

Sawyers, CL ;

Nowak, MA .

NATURE, 2005, 435 (7046) :1267-1270

← 1 2 3 4 5 6 →