Hypoxia-inducible factors, stem cells, and cancer

被引：934
作者：
Keith, Brian
Simon, M. Celeste
机构：
[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Canc Biol, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
[4] Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA
来源：
CELL | 2007年 / 129卷 / 03期
关键词：
D O I：
10.1016/j.cell.2007.04.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regions of severe oxygen deprivation (hypoxia) arise in tumors due to rapid cell division and aberrant blood vessel formation. The hypoxia-inducible factors (HIFs) mediate transcriptional responses to localized hypoxia in normal tissues and in cancers and can promote tumor progression by altering cellular metabolism and stimulating angiogenesis. Recently, HIFs have been shown to activate specific signaling pathways such as Notch and the expression of transcription factors such as Oct4 that control stem cell self renewal and multipotency. As many cancers are thought to develop from a small number of transformed, self-renewing, and multipotent "cancer stem cells," these results suggest new roles for HIFs in tumor progression.
引用
收藏
页码：465 / 472
页数：8
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