C3 and alternative pathway components are associated with an adverse lipoprotein subclass profile: The CODAM study

被引：17

作者：

Xin, Ying ^{[1
,2
,3
]}

Hertle, Elisabeth ^{[1
,2
]}

van der Kallen, Carla J. H. ^{[1
,2
]}

Vogelzangs, Nicole ^{[4
,5
]}

Arts, Ilja C. W. ^{[4
,5
]}

Schalkwijk, Casper G. ^{[1
,2
]}

Stehouwer, Coen D. A. ^{[1
,2
]}

van Greevenbroek, Marleen M. J. ^{[1
,2
]}

机构：

[1] Maastricht Univ, Dept Internal Med, Med Ctr, Univ Singel 50,POB 616, NL-6200 MD Maastricht, Netherlands

[2] Maastricht Univ, CARIM Sch Cardiovasc Dis, Univ Singel 50,POB 616, NL-6200 MD Maastricht, Netherlands

[3] Zhengzhou Univ, Affiliated Hosp 1, Dept Internal Med, Div Endocrinol, Zhengzhou, Peoples R China

[4] Maastricht Univ, CARIM Sch Cardiovasc Dis, Dept Epidemiol, Maastricht, Netherlands

[5] Maastricht Univ, Maastricht Ctr Syst Biol MaCSBio, Maastricht, Netherlands

来源：

JOURNAL OF CLINICAL LIPIDOLOGY | 2021年 / 15卷 / 02期

关键词：

Epidemiology; Human and clinical research; Lipoproteins; Lipidomics; Nuclear magnetic resonance; Lipoprotein composition; Alternative complement; ACYLATION-STIMULATING PROTEIN; MAGNETIC-RESONANCE METABOLOMICS; LOW-DENSITY-LIPOPROTEIN; COMPLEMENT C3; LONGITUDINAL ASSOCIATIONS; ADIPOSE-TISSUE; ACTIVATION; RISK; ATHEROSCLEROSIS; ASP;

D O I：

10.1016/j.jacl.2021.01.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

BACKGROUND: Plasma lipoproteins contain heterogeneous subclasses. Previous studies on the associations of the complement system with lipids and lipoproteins are mainly limited to the major lipid classes, and associations of complement with lipoprotein subclass characteristics remain unknown. OBJECTIVE: We investigated the associations of C3 and other components of the alternative complement pathway with plasma lipoprotein subclass profile. METHODS: Plasma complement concentrations (complement component 3 [C3], properdin, factor H, factor D, MASP-3, C3a, Bb), and lipoprotein subclass profile (as measured by nuclear magnetic resonance spectroscopy) were obtained in 523 participants (59.6 +/- 6.9 years, 60.8% men) of the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study. Multiple linear regression was used to investigate the associations of C3 (primary determinant) and other alternative pathway components (secondary determinants) with characteristics (particle concentration and size [main outcomes], and lipid contents [secondary outcomes]) of 14 lipoprotein subclasses, ranging from extremely large VLDL to small HDL (all standardized [std] values). RESULTS: Participants with higher C3 concentrations had more circulating VLDL (std beta s ranging from 0.27 to 0.36), IDL and LDL (std beta s ranging from 0.14 to 0.17), and small HDL (stdb = 0.21). In contrast, they had fewer very large and large HDL particles (std beta s = 20.36). In persons with higher C3 concentrations, all lipoprotein subclasses were enriched in triglycerides. Similar but weaker associations were observed for properdin, factor H, factor D, and MASP-3, but not for C3a and Bb. CONCLUSIONS: The alternative complement pathway, and most prominently C3, is associated with an adverse lipoprotein subclass profile that is characterized by more triglyceride-enriched lipoproteins but fewer large HDL. (C) 2021 National Lipid Association. Published by Elsevier Inc.

引用

页码：311 / 319

页数：9

共 39 条

[21] Shotgun proteomic analysis reveals proteome alterations in HDL of patients with cholesteryl ester transfer protein deficiency [J].