Epidemiological Aspects of Pertussis among Adults and Adolescents in a Korean Outpatient Setting: A Multicenter, PCR-Based Study

被引：19

作者：

Park, Sunghoon ^{[1
]}

Lee, Sun Hwa ^{[2
]}

Seo, Ki-Hyun ^{[3
]}

Shin, Kyeong-Cheol ^{[4
]}

Park, Yong Bum ^{[5
]}

Lee, Myung Goo ^{[6
]}

Yoo, Kwang Ha ^{[7
]}

Kim, Hui Jung ^{[8
]}

Park, Jae Seuk ^{[9
]}

Cho, Jae Hwa ^{[10
]}

Ko, Yongchun ^{[11
]}

Lee, Soo-Keol ^{[12
]}

Cheon, Ki Tae ^{[13
]}

Kim, Do Il ^{[14
]}

Ha, Jun Wook ^{[15
]}

Lee, Jae-Myung ^{[16
]}

Suhr, Ji-Won ^{[17
]}

Jeong, Eui Hun ^{[18
]}

Jung, Ki-Suck ^{[1
]}

机构：

[1] Hallym Univ, Sacred Heart Hosp, Div Pulm Allergy & Crit Care Med, Anyang 431070, South Korea

[2] Seegene Med Fdn, Seoul, South Korea

[3] Soonchunhyang Univ Hosp, Div Pulm & Crit Care Med, Cheonan, South Korea

[4] Yeungnam Univ, Med Ctr, Div Pulm Allergy & Crit Care Med, Taegu, South Korea

[5] Kangdong Sacred Heart Hosp, Div Pulm Allergy & Crit Care Med, Seoul, South Korea

[6] Chuncheon Sacred Heart Hosp, Div Pulm Allergy & Crit Care Med, Chunchon, South Korea

[7] Konkuk Univ Hosp, Div Pulm Allergy & Crit Care Med, Seoul, South Korea

[8] Wonkwnag Univ, Sanbon Hosp, Div Pulm Allergy & Crit Care Med, Gunpo, South Korea

[9] Dankook Univ Hosp, Div Pulm Allergy & Crit Care Med, Cheonan, South Korea

[10] Inha Univ Hosp, Div Pulm Allergy & Crit Care Med, Inchon, South Korea

[11] Gwangju Christian Hosp, Div Pulm Med, Kwangju, South Korea

[12] Dong A Univ Hosp, Dept Allergy, Pusan, South Korea

[13] Onnuri Clin Internal Med, Jeonju, South Korea

[14] Rapha Clin Otolaryngol, Anyang, South Korea

[15] Cheongchun Clin Internal Med, Taegu, South Korea

[16] Leejaemyeong Clin Internal Med, Anyang, South Korea

[17] Hanaro Clin Internal Med, Taejon, South Korea

[18] Hallym Clin Internal Med, Hongchon, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2014年 / 29卷 / 09期

关键词：

Pertussis; Adult; Hospitals; Incidence; Seasons; BORDETELLA-PERTUSSIS; RESURGENCE; COUGH; VACCINATION; INFECTIONS; DIPHTHERIA; DIAGNOSIS; CHILDREN; TETANUS; AGE;

D O I：

10.3346/jkms.2014.29.9.1232

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epidemiological data of Bordetella pertussis infection among adolescents and adults are limited in Korea. Patients (>= 11 yr of age) with a bothersome cough for less than 30 days were enrolled during a 1-yr period at 22 hospitals in Korea. Nasopharyngeal swabs were collected for polymerase chain reaction (PCR) and for bacteriologic culture. In total, 490 patients were finally enrolled, and 34 (6.9%) patients tested positive for B. pertussis; cough duration (14.0 days [7.0-21.0 days]) and age distribution were diverse. The incidence was the highest in secondary referral hospitals, compared to primary care clinics or tertiary referral hospitals (24/226 [10.6%] vs. 3/88 [3.4%] vs. 7/176 [4.0%], P = 0.012), and the peak incidence was observed in February and August (15.8% and 15.9%), with no confirmed cases between March and June. In the multivariate analysis, post-tussive vomiting was significantly associated with pertussis (odds ratio, 2.508; 95% confidence interval, 1.146-5.486) and secondary referral hospital showed a borderline significance. In conclusion, using a PCR-based method, 6.9% of adolescent and adult patients with an acute cough illness had pertussis infection in an outpatient setting. However, hospital levels and seasonal trends must be taken into account to develop a better strategy for controlling pertussis.

引用

页码：1232 / 1239

页数：8

共 32 条

[31] Clinical manifestations of Bordetella pertussis infection in immunized children and young adults [J].