Convenient synthesis of N-1-alkyl benzimidazoles via Pd catalyzed C-N bond formation and cyclization

被引：4

作者：

Bie, Fusheng ^{[1
]}

Yao, Yongfeng ^{[2
]}

Cao, Han ^{[1
]}

Shi, Yijun ^{[1
]}

Yan, Peng ^{[1
]}

Ma, Jie ^{[1
]}

Han, Ying ^{[1
]}

Liu, Xuejing ^{[1
]}

机构：

[1] ZaoZhuang Univ, Engn & Technol Inst LuNan Coal Chem Engn, Zaozhuang, Peoples R China

[2] Zaozhuang Ecol Environm Monitoring Ctr, Zaozhuang, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 15期

关键词：

Aromatic formamidine; benzimidazole; catalysis; cyclization; palladium; METAL-FREE SYNTHESIS; REGIOSPECIFIC SYNTHESIS; NITROGEN-HETEROCYCLES; H BOND; DERIVATIVES; AMINATION; BENZOTHIAZOLE; ALKYLATION;

D O I：

10.1080/00397911.2021.1939056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-1-Alkyl-2-unsubstituted benzimidazoles were directly synthesized by intermolecular coupling of formimidamides with benzylamines; the syntheses were catalyzed by Pd(OAc)(2) in one pot, giving rise to moderate to good yields. Aromatic formamidines with various substituents as starting materials could be readily prepared from the reactions of the corresponding anilines and N,N-dimethylformamide dimethyl acetal in high yields.

引用

页码：2387 / 2396

页数：10

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