Identification and characterization of novel hepatitis B virus subgenotype C10 in Nusa Tenggara, Indonesia

被引：43

作者：

Mulyanto ^{[2
,3
]}

Depamede, Sulaiman Ngongu ^{[2
]}

Surayah, Kiely ^{[3
]}

Tjahyono, Andreas Andhry Heru ^{[4
]}

Jirintai ^{[1
]}

Nagashima, Shigeo ^{[1
]}

Takahashi, Masaharu ^{[1
]}

Okamoto, Hiroaki ^{[1
]}

机构：

[1] Jichi Med Univ, Sch Med, Dept Infect & Immun, Div Virol, Shimotsuke, Tochigi 3290498, Japan

[2] Univ Mataram, Fac Med, Immunobiol Lab, Mataram, Indonesia

[3] W Nusa Tenggara Hepatitis Lab, Mataram, Indonesia

[4] Univ Nusa Cendana, Fac Med, Biomed Lab, Kupang, Indonesia

来源：

ARCHIVES OF VIROLOGY | 2010年 / 155卷 / 05期

关键词：

PHYLOGENETIC RELATEDNESS; COMPLETE GENOME; GENOTYPE; SEQUENCE; PAPUA; PHILIPPINES; SUBTYPE; STRAINS;

D O I：

10.1007/s00705-010-0628-x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Six novel subgenotypes (B7, B8, C6, C8, C9, and D6) within three hepatitis B virus (HBV) genotypes (B-D) were recently identified in Indonesia. To further characterize HBV in this country, 18 HBV-viremic samples obtained from blood donors in Nusa Tenggara, Indonesia, were subjected to phylogenetic analysis of an 1.6-kb partial or full-length sequence. Thirteen HBV isolates were classified into genotype B with four distinct subgenotypes [B3 (n = 2), B5 (n = 1), B7 (n = 4), and B8 (n = 6)], followed by 4 HBV isolates of genotype C (HBV/C); the remaining one isolate was of D (D1). As for the four HBV/C isolates, one isolate segregated into subgenotype C1, and two into C2. The remaining HBV/C isolate [C0901177(NT3)] differed from reported HBV/C isolates (C1-C9) by 4.6-7.7% over the entire genome and did not show evidence of recombination with any of the known HBV genotypes/subgenotypes, justifying its conclusive assignment into a novel subgenotype (C10) within genotype C.

引用

页码：705 / 715

页数：11

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