Optimization and validation of a micellar electrokinetic chromatographic method for the analysis of florfenicol

被引：24

作者：

Hillaert, S ^{[1
]}

Van den Bossche, W ^{[1
]}

机构：

[1] State Univ Ghent, Fac Pharmaceut Sci, Dept Pharmaceut Anal, Lab Pharmaceut Chem & Drug Anal, B-9000 Ghent, Belgium

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2004年 / 36卷 / 03期

关键词：

florfenicol; florfenicol amine; chloramphenicol; thiamphenicol; MEKC;

D O I：

10.1016/j.jpba.2004.07.021

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We have optimized a micellar electrokinetic capillary chromatographic method for the separation of florfenicol and florfenicol amine, its degradation product. The separation was carried out using a 50 mM sodium borate buffer (pH 9.0) containing 25 mM of sodium dodecyl sulphate. The method selectivity was proven by the simultaneous separation of florfenicol and two structural antibiotics, chloramphenicol and thiamphenicol. The same system can also be applied for the quantitative determination of these antibiotics. The method was then validated regarding linearity, precision and accuracy. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：437 / 440

页数：4

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