Dynamic roles of FGF-2 and Anosmin-1 in the migration of neuronal precursors from the subventricular zone during pre- and postnatal development

FGF-2 and Anosinin-1 are diffusible proteins which act in cell proliferation and/or migration during CNS development We describe their developmental expression patterns in the subventricular zone (SVZ) of the forebrain and the neuronal precursors (NPs) that migrate from this neurogenic site towards the olfactory bull), forming the rostral migratory stream (RMS) The analysis is carried out before (E14), during (E17, P5) and after (P15) the peaks of migration along the RMS and before this acquires its mature conformation At all these stages. FGF-2 exerts a FGFRI-mediated motogenic effect oil NPs and induces the proliferation of SVZ astrocytes (putatively type B cells front triads). and Anosinin-1 works as a typical chemotropic agent for the NPs (mechated by FGFR1 at P5-P15) Altogether. our results are consistent with the notion that FGF-2 increases cell proliferation in the SVZ and would be the motogenic cue which feeds the migration of the newly produced NPs once generated, from early development (E14) and at least until P15, while Anosmin-1 Cooperates in this migration attracting the NPs In this sense, both cues should be considered as two of the first to be chronologically identified as actors in the formation of the RMS (C) 2010 Elsevier Inc All rights reserved