Dibenzazepines and dibenzoxazepines as sodium channel blockers

被引：14
|
作者：
Lynch, Stephen M. [1 ]
Tafesse, Laykea [1 ]
Carlin, Kevin [1 ]
Ghatak, Parijat [1 ]
Kyle, Donald J. [1 ]
机构：
[1] Purdue Pharma LP, Discovery Res, Cranbury, NJ 08512 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 01期
关键词：
Neuropathic pain; Sodium channel; Na(v)1.7; Dibenzazepine; Dibenzoxazepine; NEUROPATHIC PAIN;
D O I：
10.1016/j.bmcl.2014.11.025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Na(v)1.7 in FLIPR- based and electrophysiological functional assays. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：43 / 47
页数：5
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