Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

被引：107
作者：
Huang, Ling [1 ]
Muthuswamy, Senthil K. [1 ,2 ]
机构：
[1] Univ Toronto, Ontario Canc Inst, Dept Med Biophys, Campbell Family Inst Breast Canc Res, Toronto, ON, Canada
[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 01期
关键词：
TUMOR-SUPPRESSOR GENE; NF-KAPPA-B; LETHAL GIANT LARVAE; CELL-POLARITY; KINASE-C; DIFFERENTIAL EXPRESSION; ELEVATED EXPRESSION; SOMATIC MUTATIONS; HUMAN HOMOLOG; SCRIBBLE;
D O I：
10.1016/j.gde.2009.12.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this review we discuss both gene expression and protein localization changes of polarity proteins in carcinoma. We highlight the importance of protein mislocalization and its possible role in cancer. We also discuss the emerging role of polarity proteins as regulators of proliferation, apoptosis, tissue polarity, epithelial-mesenchymal transition, in addition to their known role in cell junction biogenesis.
引用
收藏
页码：41 / 50
页数：10
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