MEDI0382, a dual GLP-1 glucagon receptor agonist, promotes rapid glucose control and significant weight loss in patients with type 2 diabetes

被引：0

作者：

Parker, V. ^{[1
]}

Ambery, P. ^{[1
]}

Robertson, D. ^{[1
]}

Posch, M. ^{[2
]}

Plum-Moerschel, L. ^{[3
]}

Wang, T. ^{[4
]}

Petrone, M. ^{[1
]}

Heise, T. ^{[5
]}

Meier, J. ^{[6
]}

Hirshberg, B. ^{[4
]}

机构：

[1] MedImmune, Cambridge, England

[2] Charite Res Org GmbH, Berlin, Germany

[3] Profil, Mainz, Germany

[4] MedImmune, Gaithersburg, MD USA

[5] Profil, Neuss, Germany

[6] Ruhr Univ, Bochum, Germany

来源：

DIABETOLOGIA | 2018年 / 61卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

164

引用

页码：S84 / S84

页数：1

共 50 条

[1] Robust glucose control and weight loss after 6 weeks of treatment with MEDI0382, a balanced GLP-1/Glucagon receptor dual agonist, in patients with type 2 diabetes
Ambery, P.
Stumvoll, M.
Posch, M.
Heise, T.
Plum-Moerschel, L.
Tsai, L. -F.
Robertson, D.
Petrone, M.
Rondinone, C.
Parker, V.
Hirshberg, B.
Jermutus, L.
DIABETOLOGIA, 2018, 61 : S362 - S362
[2] Robust Glucose Control and Weight Loss after Six Weeks of Treatment with MEDI0382, a Balanced GLP-1/Glucagon Receptor Dual Agonist, in Patients with Type 2 Diabetes
Ambery, Philip
Stumvoll, Michael W.
Posch, Maximilian G.
Heise, Tim
Plum-Moerschel, Leona
Tsai, Lan-Feng
Robertson, Darren
Petrone, Marcella
Rondinone, Cristina
Parker, Victoria E.
Hirshberg, Boaz
Jermutus, Lutz
DIABETES, 2018, 67
[3] MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, in Patients with Type 2 Diabetes-A Multiple-Ascending-Dose Study
Robertson, Darren
Stumvoll, Michael W.
Posch, Maximilian G.
Heise, Tim
Plum-Moerschel, Leona
Klein, Gernot
Tsai, Lan-Feng
Petrone, Marcella
Hirshberg, Boaz
Rondinone, Cristina
Parker, Victoria E.
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Ambery, Philip
DIABETES, 2018, 67
[4] MEDI0382, a GLP-1/glucagon receptor dual agonist, improves NASH and reduces liver fibrosis in mice
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Boland, M. L.
Conway, J.
Guionaud, S.
Grimsby, J.
Jermutus, L.
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DIABETOLOGIA, 2018, 61 : S590 - S590
[5] Medi0382, a GLP-1/glucagon receptor dual agonist, reduces weight and improves metabolism via central and peripheral actions
Baker, D.
Oldham, S.
Will, S.
Church, C.
Davies, G.
Burke, L.
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Lapointe, J. -M.
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DIABETOLOGIA, 2018, 61 : S292 - S292
[6] Acute Metabolic Effects of MEDI0382, a GLP-1/Glucagon Dual Agonist, in Wild Type and GLP-1 Receptor Knockout (GLP-1RKO) Mice
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[7] Evaluating the Sub-chronic Effects of MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, on Weight Loss in Male ob/ob Mice
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[8] MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Dramatically Reduces Hepatic Collagen in a Mouse Model of NASH
Beaton, Michelle
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Jermutus, Lutz
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DIABETES, 2019, 68
[9] MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Dramatically Reduces Hepatic Collagen in a Mouse Model of NASH
Beaton, Michelle
Guionaud, Silvia
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Rhodes, Christopher J.
Jermutus, Lutz
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DIABETES, 2018, 67
[10] MEDI0382, a GLP/Glucagon Receptor Dual Agonist, Significantly Reduces Hepatic Fat Content in Subjects with Type 2 Diabetes Mellitus
Jain, Meena
Tsai, Lan-Feng
Robertson, Darren
Hirshberg, Boaz
Hockings, Paul
Johansson, Lars
Ambery, Philip
DIABETES, 2018, 67

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