Stereoselective syntheses and reactions of stannylated peptides

被引：66

作者：

Deska, Jan ^{[1
]}

Kazmaier, Uli ^{[1
]}

机构：

[1] Univ Saarland, Inst Organ Chem, D-66123 Saarbrucken, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 24期

关键词：

allylation; cross-coupling; palladium; peptide modifications; stannanes;

D O I：

10.1002/anie.200700759

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In one fell swoop: Stannylated allyl carbonates allow the highly stereoselective synthesis of metalated peptides, which can be further modified by Stille coupling. Tin-iodine exchange generates iodinated peptides which also can be used for C-C coupling reactions. Therefore, only one stereoselective reaction is necessary to generate a wide range of different peptides in stereochemically pure form. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4570 / 4573

页数：4

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