Current trends in the management of anaemia in solid tumours and haematological malignancies

被引:13
作者
van Eeden, Ronwyn [1 ]
Rapoport, Bernardo L. [1 ]
机构
[1] Rosebank, Med Oncol Ctr, Parklands 2121,POB 2040, Johannesburg, South Africa
关键词
anaemia; cancer; cancer-related fatigue; erythropoiesis stimulating agents; iron therapy; ERYTHROPOIESIS-STIMULATING AGENTS; QUALITY-OF-LIFE; CANCER-PATIENTS; DARBEPOETIN ALPHA; INTRAVENOUS IRON; EPOETIN-ALPHA; METAANALYSIS; TRIAL; CHEMOTHERAPY; RADIOTHERAPY;
D O I
10.1097/SPC.0000000000000209
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Purpose of review Anaemia is a common problem in patients with solid tumors and haematological malignancies. Certain cancer therapies also contribute to anaemia. This article reviews the pathophysiology of cancer-related anaemia, investigation of a cancer patient with anaemia as well as how anaemia impacts patients in terms of quality of life, disease-related outcomes and treatment choices. Recent findings Different treatments for anaemia include transfusions, erythropoiesis-stimulating agents (ESA) and iron therapy. Within this context, we review the advantages and disadvantages concerning anaemia management in cancer patients as well as the risk-benefit ratio of different treatment choices, particularly the increased risk of thromboembolic events of ESAs and concern around mortality and effect on tumor growth. Summary This review is aimed at guiding treating physicians to make the best evidence-based treatment choices according to the product label and according to current guidelines for patients with cancer-related anaemia.
引用
收藏
页码:189 / 194
页数:6
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