Mode systems for regeneration: zebrafish

被引：118

作者：

Marques, Ines J. ^{[1
]}

Lupi, Eleonora ^{[1
,2
]}

Mercader, Nadia ^{[1
,3
]}

机构：

[1] Univ Bern, Inst Anat, CH-3012 Bern, Switzerland

[2] Acquifer Ditabis Digital Biomed Imaging Syst, Pforzheim, Germany

[3] CNIC, Madrid 2029, Spain

来源：

DEVELOPMENT | 2019年 / 146卷 / 18期

基金：

欧洲研究理事会;

关键词：

Regeneration; Zebrafish; Cell progenitors; Injury methods; Genetic tools; PANCREATIC BETA-CELLS; HEART REGENERATION; ADULT ZEBRAFISH; FIN REGENERATION; CARDIOMYOCYTE PROLIFERATION; KIDNEY REGENERATION; TARGETED ABLATION; SKELETAL-MUSCLE; TISSUE-GROWTH; DANIO-RERIO;

D O I：

10.1242/dev.167692

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tissue damage can resolve completely through healing and regeneration, or can produce permanent scarring and loss of function. The response to tissue damage varies across tissues and between species. Determining the natural mechanisms behind regeneration in model organisms that regenerate well can help us develop strategies for tissue recovery in species with poor regenerative capacity (such as humans). The zebrafish (Danio rerio) is one of the most accessible vertebrate models to study regeneration. In this Primer, we highlight the tools available to study regeneration in the zebrafish, provide an overview of the mechanisms underlying regeneration in this system and discuss future perspectives for the field.

引用

页数：13

共 183 条

[1] Heat-inducible expression of a reporter gene detected by transient assay in zebrafish [J].