Assessment and interpretation of sleep disordered breathing severity in cardiology: Clinical implications and perspectives

被引：60

作者：

Linz, Dominik ^{[1
,2
]}

Baumert, Mathias ^{[3
]}

Catcheside, Peter ^{[4
,5
,6
]}

Floras, John ^{[7
,8
]}

Sanders, Prashanthan ^{[1
,2
]}

Levy, Patrick ^{[9
,10
]}

Cowie, Martin R. ^{[11
]}

McEvoy, R. Doug ^{[4
,5
,6
]}

机构：

[1] Univ Adelaide, SAHMRI, CHRD, Adelaide, SA, Australia

[2] Royal Adelaide Hosp, Adelaide, SA, Australia

[3] Univ Adelaide, Sch Elect & Elect Engn, Adelaide, SA, Australia

[4] Flinders Univ S Australia, Coll Med & Publ Hlth, AISH, Adelaide, SA, Australia

[5] Flinders Univ S Australia, Coll Med & Publ Hlth, Sch Med, Adelaide, SA, Australia

[6] Southern Adelaide Local Hlth Network, Sleep Hlth Serv, Resp & Sleep Serv, Adelaide, SA, Australia

[7] Univ Toronto, Univ Hlth Network, Toronto, ON, Canada

[8] Univ Toronto, Div Cardiol, Sinai Hlth Syst, Toronto, ON, Canada

[9] Univ Grenoble Alpes, INSERM, CHU Grenoble Alpes, HP2, Grenoble, France

[10] Univ Grenoble Alpes, INSERM, CHU Grenoble Alpes, Sleep Lab, Grenoble, France

[11] Imperial Coll London, Royal Brompton Hosp, Natl Heart & Lung Inst, London, England

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2018年 / 271卷

基金：

英国医学研究理事会;

关键词：

Sleep disordered breathing; Atrial fibrillation; Arrhythmias; Hypoxia; Sleep apnea; Heart failure; POSITIVE AIRWAY PRESSURE; ADAPTIVE SERVO-VENTILATION; SYMPATHETIC-NERVE ACTIVITY; OBSTRUCTIVE RESPIRATORY EVENTS; CHEYNE-STOKES RESPIRATION; HEART-FAILURE PATIENTS; BETA-BLOCKER TREATMENT; TO-NIGHT VARIABILITY; 2016 ESC GUIDELINES; BLOOD-PRESSURE;

D O I：

10.1016/j.ijcard.2018.04.076

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sleep disordered breathing (SDB) is highly prevalent in patients with atrial fibrillation, heart failure and hypertension and is associated with increased risk of mortality, cardiovascular (CV) events and arrhythmias. Current assessment of the severity of SDB is mainly based on the apnea-hypopnea index (AHI) representing the number of hypopneas and apneas per hour of sleep. However, this event-based parameter alone may not sufficiently reflect the complex pathophysiological mechanisms underlying SDB potentially contributing to CV outcome risk. In this review article, we highlight important limitations and pitfalls of current assessment, quantification and interpretation of SDB-severity in patients with CV disease and will discuss pathophysiological considerations from preclinical and clinical mechanistic studies and possible clinical implications. (c) 2018 Elsevier B.V. All rights reserved.

引用

页码：281 / 288

页数：8

共 100 条

[91] Effects of continuous positive airway pressure on obstructive sleep apnea and left ventricular afterload in patients with heart failure [J].