Evaluation of the In Vitro Activity of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Meropenem-Resistant Pseudomonas aeruginosa Isolates

被引：85

作者：

Buehrle, Deanna J. ^{[1
]}

Shields, Ryan K. ^{[2
,3
]}

Chen, Liang ^{[4
]}

Hao, Binghua ^{[3
]}

Press, Ellen G. ^{[2
]}

Alkrouk, Ammar ^{[2
]}

Potoski, Brian A. ^{[1
]}

Kreiswirth, Barry N.

Clancy, Cornelius J. ^{[2
,3
,5
]}

Nguyen, M. Hong ^{[2
,3
]}

机构：

[1] Univ Pittsburgh, Dept Pharm & Therapeut, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[3] Univ Pittsburgh, Med Ctr, XDR Pathogen Lab, Pittsburgh, PA USA

[4] Rutgers State Univ, Sch Med, Newark, NJ 07102 USA

[5] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 05期

基金：

美国国家卫生研究院;

关键词：

BETA-LACTAM RESISTANCE; BLOOD-STREAM INFECTIONS; GRAM-NEGATIVE ORGANISMS; US MEDICAL-CENTERS; CARBAPENEM RESISTANCE; KLEBSIELLA-PNEUMONIAE; MEDITERRANEAN COUNTRIES; CXA-101; FR264205; MECHANISMS; ENTEROBACTERIACEAE;

D O I：

10.1128/AAC.02969-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We compared ceftazidime-avibactam, ceftolozane-tazobactam, ceftazidime, cefepime, and piperacillin-tazobactam MICs for 38 meropenem-resistant Pseudomonas aeruginosa isolates. No isolates harbored carbapenemases; 74% were oprD mutants. Ceftazidime-avibactam and ceftolozane-tazobactam were active against 92% of the isolates, including 80% that were resistant to all three beta-lactams. Forty-three percent of ceftazidime-avibactam-susceptible isolates and 6% of ceftolozane-tazobactam-susceptible isolates exhibited MICs at the respective breakpoints. Ceftolozane-tazobactam and ceftazidime-avibactam are therapeutic options for meropenem-resistant P. aeruginosa infections that should be used judiciously to preserve activity.

引用

页码：3227 / 3231

页数：5

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