Neuroendocrine regulation of sebocytes -: a pathogenetic link between stress and acne

被引：106
作者：
Zouboulis, CC
Böhm, M
机构：
[1] Charite Univ Med Berlin, Dept Dermatol, D-14195 Berlin, Germany
[2] Univ Munster, Dept Dermatol, D-4400 Munster, Germany
[3] Univ Munster, Ludwig Boltzmann Inst Cell Biol & Immunobiol Skin, D-4400 Munster, Germany
来源：
EXPERIMENTAL DERMATOLOGY | 2004年 / 13卷
关键词：
acne; neuropeptides; sebaceous gland; sebocytes; stress;
D O I：
10.1111/j.1600-0625.2004.00254.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
A causative link between emotional stress and acne has long been postulated. There is mounting evidence that the molecular mechanism underlying this observation is related to the expression of receptors for several neuroendocrine mediators by the sebaceous gland. Recent and ongoing studies have indicated that human sebocytes express functional receptors for corticotropin-releasing hormone, melanocortins, beta-endorphin, vasoactive intestinal polypeptide, neuropeptide Y and calcitonin gene-related peptide. After ligand binding, these receptors modulate the production of inflammatory cytokines, proliferation, differentiation, lipogenesis and androgen metabolism in sebocytes. By means of their autocrine, paracrine and endocrine actions, these neuroendocrine factors appear to mediate centrally and topically induced stress towards the sebaceous gland, ultimately affecting the clinical course of acne.
引用
收藏
页码：31 / 35
页数：5
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