Application of Electron Paramagnetic Resonance (EPR) spectroscopy and imaging in drug delivery research - Chances and challenges

被引：65

作者：

Kempe, Sabine ^{[1
]}

Metz, Hendrik ^{[1
]}

Maeder, Karsten ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Inst Pharm, Dept Pharmaceut & Biopharmaceut, D-06120 Halle, Germany

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2010年 / 74卷 / 01期

关键词：

EPR; ESR; Election Spin Resonance; Electron Paramagnetic Resonance; Drug delivery; EPR imaging; In vivo; NUCLEAR-MAGNETIC-RESONANCE; IN-VIVO DETECTION; BIODEGRADABLE POLYMERS; TUMOR OXYGENATION; TRITYL RADICALS; SPIN PROBES; HUMAN SKIN; PH; ESR; RELEASE;

D O I：

10.1016/j.ejpb.2009.08.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Electron Paramagnetic Resonance (EPR) spectroscopy is a powerful technique to Study chemical species with unpaired electrons. Since its discovery in 1944, it has been widely used in a number of research fields such as physics, chemistry, biology and material and food science. This review is focused on its application in drug delivery research. EPR permits the direct measurement of microviscosity and micro-polarity inside drug delivery systems (DDS), the detection of microacidity, phase transitions and the characterization of colloidal drug carriers. Additional information about the spatial distribution can be obtained by EPR imaging. The chances and also the challenges of in vitro and in vivo EPR spectroscopy and imaging in the field of drug delivery are discussed. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：55 / 66

页数：12

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