Conformations of a synthetic peptide which facilitates the cellular delivery of nucleic acids

被引：2

作者：

Vidal, P ^{[1
]}

Morris, MC ^{[1
]}

Chaloin, L ^{[1
]}

Mery, J ^{[1
]}

Heitz, F ^{[1
]}

Divita, G ^{[1
]}

机构：

[1] CNRS, CRBM, ERS 0155, F-34033 Montpellier, France

来源：

LETTERS IN PEPTIDE SCIENCE | 1997年 / 4卷 / 4-6期

关键词：

cellular uptake; vector peptide; conformation; circular dichroism;

D O I：

10.1023/A:1008899427075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the synthesis of an amphipathic vector peptide which is able to form complexes with nucleic acids. Based on circular dichroism investigations, the nature of the structure obtained in water is questioned. The peptide adopts an alpha-helical structure in TFE and is partially in a beta-sheet conformation in phosphate buffer at low peptide concentrations.

引用

页码：227 / 230

页数：4

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