Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism

被引：70

作者：

Nishimura, Katsuhiko

Nakamura, Kazuhiko ^{[1
]}

Anitha, A.

Yamada, Kazuo

Tsujii, Masatsugu

Iwayama, Yoshimi

Hattori, Eiji

Toyota, Tomoko

Takei, Nori

Miyachi, Taishi

Iwata, Yasuhide

Suzuki, Katsuaki

Matsuzaki, Hideo

Kawai, Masayoshi

Sekine, Yoshimoto

Tsuchiya, Kenji

Sugihara, Gen-ichi

Suda, Shiro

Ouchi, Yasuomi

Sugiyama, Toshiro

Yoshikawa, Takeo

Mori, Norio

机构：

[1] Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 43131, Japan

[2] RIKEN, Brain Sci Inst, Lab Mol Psychiat, Saitama, Japan

[3] Chukyo Univ, Fac Sociol, Toyota, Aichi, Japan

[4] Hamamatsu Univ Sch Med, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Hamamatsu, Shizuoka 43131, Japan

[5] Osaka Univ, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Grad Sch Med, Suita, Osaka 565, Japan

[6] Hamamatsu Med Ctr, Positron Med Ctr, Hamamatsu, Shizuoka, Japan

[7] Aichi Childrens Hlth & Med Ctr, Aichi, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 356卷 / 01期

关键词：

autism; brain-derived neurotrophic factor; serotonin transporter; a trios-based association; peripheral blood lymphocytes;

D O I：

10.1016/j.bbrc.2007.02.135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autism is a severe neurodevelopmental disorder defined by social and communication deficits and ritualistic-repetitive behaviors that are detectable in early childhood. Brain-derived neurotrophic factor (BDNF) plays a critical role in the pathogenesis of autism. In this study, we examined the SNP- and haplotypic-association of BDNF with autism in a trios-based association study (the Autism Genetic Resource Exchange). We also examined the expression of BDNF mRNA in the peripheral blood lymphocytes of drug-naive autism patients and control subjects. In the TDT of autism trios, the SNP haplotype combinations showed significant associations in the autism group. BDNF expression in the drug-naive autistic group was found to be significantly higher than in the control group. We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：200 / 206

页数：7

共 49 条

[1] THE NEUROTROPHINS NT-4/5 AND BDNF AUGMENT SEROTONIN, DOPAMINE, AND GABAERGIC SYSTEMS DURING BEHAVIORALLY EFFECTIVE INFUSIONS TO THE SUBSTANTIA-NIGRA [J].