Evaluation of Antioxidant Activities of Ampelopsin and Its Protective Effect in Lipopolysaccharide-Induced Oxidative Stress Piglets

被引：61

作者：

Hou, Xiang ^{[1
]}

Zhang, Jingfei ^{[1
]}

Ahmad, Hussain ^{[1
]}

Zhang, Hao ^{[1
]}

Xu, Ziwei ^{[1
,2
]}

Wang, Tian ^{[1
]}

机构：

[1] Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing, Jiangsu, Peoples R China

[2] Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou, Zhejiang, Peoples R China

来源：

PLOS ONE | 2014年 / 9卷 / 09期

关键词：

MOLECULAR-MECHANISMS; LIVER-INJURY; ENDOTOXIN; DAMAGE; ERYTHROCYTES; EXTRACT; CELL; HEMOLYSIS; TOXICITY; FRUITS;

D O I：

10.1371/journal.pone.0108314

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of this study was to investigate the antioxidant potential of ampelopsin (APS) by using various methods in vitro, as well as to determine effects of APS on LPS-induced oxidative stress in piglets. The results showed that APS exhibited excellent free radical scavenging by DPPH, ABTS, O-2 center dot(-), H2O2 and ferric reducing antioxidant power. Ampelopsin also protected pig erythrocytes against AAPH-induced apoptosis and hemolysis, decreased total superoxide dismutase activity, and increased lipid peroxidation. Furthermore the results demonstrated that APS enhanced the total antioxidant capacity and decreased the malondialdehyde and protein carbonyl contents in LPS-treated piglets. The results of the present investigation suggest that APS possesses a strong antioxidant activity and alleviates LPS-induced oxidative stress, possibly due to its ability to prevent reactive oxygen species.

引用

页数：10

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