Wnt Signaling Pathway in Schizophrenia

被引：17

作者：

Peng, Yanmin ^{[1
]}

Xu, Yifeng ^{[1
]}

Cui, Donghong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Key Lab Translat Psychiat, Shanghai 200030, Peoples R China

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2014年 / 13卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Adenomatous polyposis coli; glycogen synthase kinase-3; schizophrenia; Wnt signaling pathway; ADENOMATOUS-POLYPOSIS-COLI; MEDIAL PREFRONTAL CORTEX; SENSITIZED ANIMALS SHOW; LONG-TERM POTENTIATION; RECEPTOR SUBUNIT GENE; FRIZZLED-3; FZD3; GENE; BETA-CATENIN; WNT/BETA-CATENIN; VENTRAL MIDBRAIN; TRANSGENIC MICE;

D O I：

10.2174/1871527312666131223113521

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Wnt signaling pathway is one of the crucial signaling pathways that regulate many aspects of central nervous system. In this review, we tempt to depict an overall picture of the Wnt signaling with its multitude of roles in schizophrenia. If the Wnt signaling pathway plays a crucial role in the pathogenesis of schizophrenia as we suggest, a better understanding of the Wnt pathway might contribute to developing new and more effective tools for diagnosis and treatment of schizophrenia.

引用

页码：755 / 764

页数：10

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