Wnt Signaling Pathway in Schizophrenia

被引：17
|
作者：
Peng, Yanmin [1 ]
Xu, Yifeng [1 ]
Cui, Donghong [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Key Lab Translat Psychiat, Shanghai 200030, Peoples R China
来源：
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2014年 / 13卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Adenomatous polyposis coli; glycogen synthase kinase-3; schizophrenia; Wnt signaling pathway; ADENOMATOUS-POLYPOSIS-COLI; MEDIAL PREFRONTAL CORTEX; SENSITIZED ANIMALS SHOW; LONG-TERM POTENTIATION; RECEPTOR SUBUNIT GENE; FRIZZLED-3; FZD3; GENE; BETA-CATENIN; WNT/BETA-CATENIN; VENTRAL MIDBRAIN; TRANSGENIC MICE;
D O I：
10.2174/1871527312666131223113521
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The Wnt signaling pathway is one of the crucial signaling pathways that regulate many aspects of central nervous system. In this review, we tempt to depict an overall picture of the Wnt signaling with its multitude of roles in schizophrenia. If the Wnt signaling pathway plays a crucial role in the pathogenesis of schizophrenia as we suggest, a better understanding of the Wnt pathway might contribute to developing new and more effective tools for diagnosis and treatment of schizophrenia.
引用
收藏
页码：755 / 764
页数：10
相关论文
共 50 条
  • [1] Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder
    Hoseth, Eva Z.
    Krull, Florian
    Dieset, Ingrid
    Morch, Ragni H.
    Hope, Sigrun
    Gardsjord, Erlend S.
    Steen, Nils Eiel
    Melle, Ingrid
    Brattbakk, Hans-Richard
    Steen, Vidar M.
    Aukrust, Pal
    Djurovic, Srdjan
    Andreassen, Ole A.
    Ueland, Thor
    TRANSLATIONAL PSYCHIATRY, 2018, 8
  • [2] Wnt Signaling: Role in Alzheimer Disease and Schizophrenia
    Inestrosa, Nibaldo C.
    Montecinos-Oliva, Carla
    Fuenzalida, Marco
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2012, 7 (04) : 788 - 807
  • [3] The Wnt signaling pathway in solid childhood tumors
    Koesters, R
    Doeberitz, MV
    CANCER LETTERS, 2003, 198 (02) : 123 - 138
  • [4] Expression study of Wnt/β-catenin signaling pathway associated lncRNAs in schizophrenia
    Manafzadeh, Fatemeh
    Baradaran, Behzad
    Azar, Seyed Gholamreza Noor
    Aghdam, Kamran Javidi
    Dabbaghipour, Reza
    Shayannia, Asghar
    Ghafouri-Fard, Soudeh
    ANNALS OF GENERAL PSYCHIATRY, 2025, 24 (01)
  • [5] The genetic factors associated with Wnt signaling pathway in colorectal cancer
    Aghabozorgi, Amirsaeed Sabeti
    Ebrahimi, Reyhane
    Bahiraee, Alireza
    Tehrani, Sadra Samavarchi
    Nabizadeh, Fatemeh
    Setayesh, Leila
    Jafarzadeh-Esfehani, Reza
    Ferns, Gordon A.
    Avan, Amir
    Rashidi, Zahra
    LIFE SCIENCES, 2020, 256
  • [6] Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling
    Lorzadeh, Shahrokh
    Kohan, Leila
    Ghavami, Saeid
    Azarpira, Negar
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2021, 1868 (03):
  • [7] Effect of Wnt signaling pathway on wound healing
    Zhang, D. L.
    Gu, L. J.
    Liu, L.
    Wang, C. Y.
    Sun, B. S.
    Li, Z.
    Sung, C. K.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 378 (02) : 149 - 151
  • [8] Curcumin Therapeutic Modulation of the Wnt Signaling Pathway
    Ashrafizadeh, Milad
    Ahmadi, Zahra
    Mohamamdinejad, Reza
    Yaribeygi, Habib
    Serban, Maria-Corina
    Orafai, Hossein M.
    Sahebkar, Amirhossein
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2020, 21 (11) : 1006 - 1015
  • [9] Epigenetic Regulation of the Wnt/β-Catenin Signaling Pathway in Cancer
    Sharma, Ankita
    Mir, Rafeeq
    Galande, Sanjeev
    FRONTIERS IN GENETICS, 2021, 12
  • [10] Expression of WNT Signaling Genes in the Dorsolateral Prefrontal Cortex in Schizophrenia
    Sahay, Smita
    Hamoud, Abdul-rizaq
    Osman, Mahasin
    Pulvender, Priyanka
    McCullumsmith, Robert E.
    BRAIN SCIENCES, 2024, 14 (07)
12345