Molecular mechanisms of brain-derived neurotrophic factor in neuroprotection: Recent developments

被引：96

作者：

Zhao, Hailin ^{[1
]}

Alam, Azeem ^{[1
]}

San, Chun-Yin ^{[1
]}

Eguchi, Shiori ^{[1
]}

Chen, Qian ^{[1
,3
]}

Lian, Qingquan ^{[2
]}

Ma, Daqing ^{[1
]}

机构：

[1] Imperial Coll London, Chelsea & Westminster Hosp, Anaesthet Pain Med & Intens Care, Fac Med,Dept Surg & Canc, London, England

[2] Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Wenzhou, Peoples R China

[3] Third Mil Med Univ, Southwest Hosp, Dept Anaesthesiol, Chongqing, Peoples R China

来源：

BRAIN RESEARCH | 2017年 / 1665卷

关键词：

Brain-derived neurotrophic factor; Neuroprotection; Brain injury; MESENCHYMAL STEM-CELLS; FACTOR VAL66MET POLYMORPHISM; MILD COGNITIVE IMPAIRMENT; CENTRAL-NERVOUS-SYSTEM; ALZHEIMER NEUROFIBRILLARY DEGENERATION; FAMILY TRANSCRIPTION FACTOR; AMYLOID PRECURSOR PROTEIN; MESSENGER-RNA EXPRESSION; LONG-TERM HIPPOCAMPAL; FACTOR GENE DELIVERY;

D O I：

10.1016/j.brainres.2017.03.029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a significant cause of mortality around the world. On a molecular level, the condition is characterized by widespread cell death and poor regeneration, which can result in severe morbidity in survivors. Potential therapeutics are of major interest, with a promising candidate being brain-derived neurotrophic factor (BDNF), a ubiquitous agent in the brain which has been associated with neural development and may facilitate protective and regenerative effects following injury. This review summarizes the available information on the potential benefits of BDNF and the molecular mechanisms involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer's disease and Parkinson's disease. It further explores the methods in which BDNF can be applied in clinical and therapeutic settings, and the potential challenges to overcome. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：1 / 21

页数：21

共 335 条

[1] Mouse and rat BDNF gene structure and expression revisited [J].

Aid, Tamara ;

Kazantseva, Anna ;

Piirsoo, Marko ;

Palm, Kaia ;

Timmusk, Tonis .

JOURNAL OF NEUROSCIENCE RESEARCH, 2007, 85 (03) :525-535

[2] Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan [J].

Akatsu, Hiroyasu ;

Yamagata, Hidehisa D. ;

Kawamata, Jun ;

Kamino, Kouzin ;

Takeda, Masatoshi ;

Yamamoto, Takayuki ;

Miki, Tetsuro ;

Tooyama, Ikuo ;

Shimohama, Shun ;

Kosaka, Kenji .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2006, 22 (03) :216-222

[3] Effect of BDNF Val66Met Polymorphism on Normal Variability of Executive Functions [J].

Alfimova, M. V. ;

Korovaitseva, G. I. ;

Lezheiko, T. V. ;

Golimbet, V. E. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2012, 152 (05) :606-609

[4] Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways [J].

Almeida, RD ;

Manadas, BJ ;

Melo, CV ;

Gomes, JR ;

Mendes, CS ;

Graos, MM ;

Carvalho, RF ;

Carvalho, AP ;

Duarte, CB .

CELL DEATH AND DIFFERENTIATION, 2005, 12 (10) :1329-1343

[5] Abnormal phosphorylation of tan and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau [J].

Alonso, AD ;

GrundkeIqbal, I ;

Barra, HS ;

Iqbal, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (01) :298-303

[6] Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules [J].

Alonso, AD ;

GrundkeIqbal, I ;

Iqbal, K .

NATURE MEDICINE, 1996, 2 (07) :783-787

[7]

Alonso AD, 2001, J BIOL CHEM, V276, P37967

[8] ROLE OF ABNORMALLY PHOSPHORYLATED TAN IN THE BREAKDOWN OF MICROTUBULES IN ALZHEIMER-DISEASE [J].

ALONSO, AD ;

ZAIDI, T ;

GRUNDKEIQBAL, I ;

IQBAL, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (12) :5562-5566

[9] Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) Patients are Characterized by Increased BDNF Serum Levels [J].

Angelucci, F. ;

Spalletta, G. ;

di Iulio, F. ;

Ciaramella, A. ;

Salani, F. ;

Varsi, A. E. ;

Gianni, W. ;

Sancesario, G. ;

Caltagirone, C. ;

Bossu, P. .

CURRENT ALZHEIMER RESEARCH, 2010, 7 (01) :15-20

[10] Increased Concentrations of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in the Rat Cerebellum After Exposure to Environmental Enrichment [J].

Angelucci, Francesco ;

De Bartolo, Paola ;

Gelfo, Francesca ;

Foti, Francesca ;

Cutuli, Debora ;

Bossu, Paola ;

Caltagirone, Carlo ;

Petrosini, Laura .

CEREBELLUM, 2009, 8 (04) :499-506

← 1 2 3 4 5 6 7 8 9 10 →