Photo-Cross-Linked PDMSstar-PEG Hydrogels: Synthesis, Characterization, and Potential Application for Tissue Engineering Scaffolds

被引：100

作者：

Hou, Yaping ^{[1
]}

Schoener, Cody A. ^{[1
]}

Regan, Katherine R. ^{[1
]}

Munoz-Pinto, Dany ^{[2
]}

Hahn, Mariah S. ^{[2
]}

Grunlan, Melissa A. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA

[2] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA

来源：

BIOMACROMOLECULES | 2010年 / 11卷 / 03期

关键词：

EXTRACELLULAR-MATRIX; MECHANICAL-PROPERTIES; PROTEIN ADSORPTION; GELATIN-SILOXANE; CELL ADHESIVE; MESH SIZE; BIOMATERIALS; PHOTOENCAPSULATION; CYTOCOMPATIBILITY; CHONDROCYTES;

D O I：

10.1021/bm9012293

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inorganic-organic hydrogels with tunable chemical and physical properties were prepared from methacrylated star polydimethylsiloxane (PDMSstar-MA) and diacrylated poly(ethylene glycol) (PEG-DA) for use as tissue engineering scaffolds. A total of 18 compositionally unique hydrogels were prepared by photo-cross-linking, varying weight ratios of PEG-DA and PDMSstar-MA of different molecular weights (M-n): PEG-DA (M-n = 3.4k and 6k g/mol) and PDMSstar-MA (M-n = 1.8k, 5k, and 7k g/mol). Introduction of PDMSstar-MA Caused formation of discrete PDMS-enriched microparticles dispersed within the PEG matrix. The swelling ratio, mechanical properties in tension and compression, nonspecific protein adhesion, controlled introduction of bioactivity, and cytotoxicity of hydrogels Were studied. This library of inorganic-organic hydrogels with tunable properties provides U useful platform to study the effect of scaffold properties on cell behavior.

引用

页码：648 / 656

页数：9

共 63 条

[1]

Agrawal CM, 2001, J BIOMED MATER RES, V55, P141, DOI 10.1002/1097-4636(200105)55:2<141::AID-JBM1000>3.3.CO

[2]

2-A

[3] PROTEIN ADSORPTION AND MACROPHAGE ACTIVATION ON POLYDIMETHYLSILOXANE AND SILICONE-RUBBER [J].

ANDERSON, JM ;

ZIATS, NP ;

AZEEZ, A ;

BRUNSTEDT, MR ;

STACK, S ;

BONFIELD, TL .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 1995, 7 (02) :159-169

[4] Mechanical properties of hydrogels and their experimental determination [J].

Anseth, KS ;

Bowman, CN ;

BrannonPeppas, L .

BIOMATERIALS, 1996, 17 (17) :1647-1657

[5] Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells [J].

Benoit, Danielle S. W. ;

Schwartz, Michael P. ;

Durney, Andrew R. ;

Anseth, Kristi S. .

NATURE MATERIALS, 2008, 7 (10) :816-823

[6]

Boutevin B, 2000, J POLYM SCI POL CHEM, V38, P3722, DOI 10.1002/1099-0518(20001015)38:20<3722::AID-POLA20>3.0.CO

[7]

2-C

[8] Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitro [J].

Bryant, SJ ;

Nuttelman, CR ;

Anseth, KS .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2000, 11 (05) :439-457

[9] Manipulations in hydrogel chemistry control photoencapsulated chondrocyte behavior and their extracellular matrix production [J].

Bryant, SJ ;

Durand, KL ;

Anseth, KS .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2003, 67A (04) :1430-1436

[10] Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels [J].

Bryant, SJ ;

Anseth, KS .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 59 (01) :63-72

← 1 2 3 4 5 6 7 →