Managing patients with sickle cell disease in primary care

被引:5
作者
Hehre, Robert J. [1 ,2 ]
机构
[1] Ovi & Violet Int Inc, Somerset, KY 42503 USA
[2] OVI Childrens Hosp Suna, Migori, Kenya
来源
JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS | 2020年 / 33卷 / 10期
关键词
sickle cell disease; anemia; erythrocytes; blood disorder; health maintenance; hydroxyurea; HYDROXYUREA; CHILDREN; THERAPY; PHASE-3; ANEMIA;
D O I
10.1097/01.JAA.0000697232.25913.b1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sickle cell disease (SCD) is a group of disorders affecting the hemoglobin in erythrocytes. SCD is associated with significant morbidity and mortality and occurs most commonly among people of African ancestry. In 2014, the National Heart, Lung, and Blood Institute updated its guidelines for the management of SCD. These guidelines were implemented to provide evidence-based recommendations to assist primary care clinicians in the proper management of patients with SCD. This article reviews the current practice guidelines for SCD, with attention to health maintenance and hydroxyurea.
引用
收藏
页码:21 / 28
页数:8
相关论文
共 31 条
[11]   Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease [J].
Gladwin, MT ;
Shelhamer, JH ;
Ognibene, FP ;
Pease-Fye, ME ;
Nichols, JS ;
Link, B ;
Patel, DB ;
Jankowski, MA ;
Pannell, LK ;
Schechter, AN ;
Rodgers, GP .
BRITISH JOURNAL OF HAEMATOLOGY, 2002, 116 (02) :436-444
[12]   From Infancy to Adolescence: Fifteen Years of Continuous Treatment With Hydroxyurea in Sickle Cell Anemia [J].
Hankins, Jane S. ;
Aygun, Banu ;
Nottage, Kerri ;
Thornburg, Courtney ;
Smeltzer, Matthew P. ;
Ware, Russell E. ;
Wang, Winfred C. .
MEDICINE, 2014, 93 (28) :e215
[13]   Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease [J].
Hoban, Megan D. ;
Orkin, Stuart H. ;
Bauer, Daniel E. .
BLOOD, 2016, 127 (07) :839-848
[14]   The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease [J].
Koehl, Berengere ;
Nivoit, Pierre ;
El Nemer, Wassim ;
Lenoir, Olivia ;
Hermand, Patricia ;
Pereira, Catia ;
Brousse, Valentine ;
Guyonnet, Lea ;
Ghinatti, Giulia ;
Benkerrou, Malika ;
Colin, Yves ;
Le Van Kim, Caroline ;
Tharaux, Pierre-Louis .
HAEMATOLOGICA, 2017, 102 (07) :1161-1172
[15]   Survival Among Children and Adults With Sickle Cell Disease in Belgium: Benefit From Hydroxyurea Treatment [J].
Le, Phu Quoc ;
Gulbis, Beatrice ;
Dedeken, Laurence ;
Dupont, Sophie ;
Vanderfaeillie, Anna ;
Heijmans, Catherine ;
Huybrechts, Sophie ;
Devalck, Christine ;
Efira, Andre ;
Dresse, Marie-Francoise ;
Rozen, Laurence ;
Benghiat, Fleur Samantha ;
Ferster, Alina .
PEDIATRIC BLOOD & CANCER, 2015, 62 (11) :1956-1961
[16]   Immunologic Effects of Hydroxyurea in Sickle Cell Anemia [J].
Lederman, Howard M. ;
Connolly, Margaret A. ;
Kalpatthi, Ram ;
Ware, Russell E. ;
Wang, Winfred C. ;
Luchtman-Jones, Lori ;
Waclawiw, Myron ;
Goldsmith, Jonathan C. ;
Swift, Andrea ;
Casella, James F. .
PEDIATRICS, 2014, 134 (04) :686-695
[17]  
Lunyera J, 2017, J PRIM CARE COMMUNIT, V8, P37, DOI 10.1177/2150131916662969
[18]   Hydroxyurea therapy for sickle cell anemia [J].
McGann, Patrick T. ;
Ware, Russell E. .
EXPERT OPINION ON DRUG SAFETY, 2015, 14 (11) :1749-1758
[19]  
National Institute of Health National Heart Lung and Blood Institute, 2014, EVIDENCE BASED MANAG
[20]   A Phase 3 Trial of L-Glutamine in Sickle Cell Disease [J].
Niihara, Yutaka ;
Miller, Scott T. ;
Kanter, Julie ;
Lanzkron, Sophie ;
Smith, Wally R. ;
Hsu, Lewis L. ;
Gordeuk, Victor R. ;
Viswanathan, Kusum ;
Sarnaik, Sharada ;
Osunkwo, Ifeyinwa ;
Guillaume, Edouard ;
Sadanandan, Swayam ;
Sieger, Lance ;
Lasky, Joseph L. ;
Panosyan, Eduard H. ;
Blake, Osbourne A. ;
New, Tamara N. ;
Bellevue, Rita ;
Tran, Lan T. ;
Razon, Rafael L. ;
Stark, Charles W. ;
Neumayr, Lynne D. ;
Vichinsky, Elliott P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (03) :226-235