Kalanchoe laciniata and Bryophyllum pinnatum: an updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology

被引：36

作者：

Fernandes, Julia M. ^{[1
]}

Cunha, Lorena M. ^{[1
]}

Azevedo, Eduardo Pereira ^{[3
]}

Lourenco, Estela M. G. ^{[1
]}

Fernandes-Pedrosa, Matheus F. ^{[2
]}

Zucolotto, Silvana M. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Norte, Dept Farm, Lab Farmacognosia, Natal, RN, Brazil

[2] Univ Fed Rio Grande do Norte, Lab Tecnol & Biotecnol Farmaceut, Natal, RN, Brazil

[3] Univ Fed Rio Grande do Norte, Dept Farm, Lab Farmacotecn, Natal, RN, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2019年 / 29卷 / 04期

关键词：

Comparison; Flavonoid; Traditional use; Phytochemical; Pharmacology; Toxicology; CRASSULACEAN ACID METABOLISM; UTTARA-KANNADA DISTRICT; MEDICINAL-PLANTS; AQUEOUS EXTRACT; TRADITIONAL HEALERS; LEAF EXTRACT; ANTIINFLAMMATORY ACTIVITY; DETRUSOR CONTRACTILITY; ANTIMICROBIAL ACTIVITY; ETHNOMEDICINAL PLANTS;

D O I：

10.1016/j.bjp.2019.01.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The species Kalanchoe laciniata (L.) DC. and Bryophyllum pinnatum (Lam) Pers. are native from Brazil and Madagascar, respectively. Both belonging to the Crassulaceae family and being widely used by population as a natural anti-inflammatory agent. These species have similar leaf morphology and for this reason, they are known by the same popular name as "saido" or "coirama". Several studies have been published involving different parts and preparations of these species. Therefore, this review aims to provide an update overview about the traditional uses, chemical constitution, pharmacology and toxicology of K. laciniata and B. pinnatum species. An extensive literature review was conducted in different scientific databases. Various chemical constituents have been identified in extracts from different parts of K. laciniata and B. pinnatum, being flavonoids the major compounds. They have been traditionally used to treat inflammation, microbial infection, pain, respiratory diseases, gastritis, ulcers, diabetes and cancer tumors. Non-clinical in vitro assays evaluated mainly the antimicrobial and antioxidant activities, while in vivo assays evaluated the leishmanicide, anti-inflammatory and immunomodulatory activities. Regarding toxicity, few studies have been conducted for the two species. The information reported in this work might contribute to the recognition of the importance of K. laciniata and B. pinnatum species, as well as to direct further studies. (C) 2019 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Farmacognosia.

引用

页码：529 / 558

页数：30

共 238 条

[11]

Akpantah AO., 2014, Eur J Biol Med Sci Res, V2, P37

[12]

Albertasse P. D., 2010, Revista Brasileira de Plantas Medicinais, V12, P250

[13]

Alhaji U. I., 2014, Asian Pacific Journal of Tropical Disease, V4, P348, DOI 10.1016/S2222-1808(14)60586-7

[14]

AllorgeBoiteau L, 1996, COLLOQ SEMI, P137

[15]

Almeida Ana P., 2006, Rev. bras. farmacogn., V16, P485, DOI 10.1590/S0102-695X2006000400008

[16] Isolation and chemical analysis of a fatty acid fraction of Kalanchoe pinnata with a potent lymphocyte suppressive activity [J].

Almeida, AP ;

Da Silva, SAG ;

Souza, MLM ;

Lima, LMTR ;

Rossi-Bergmann, B ;

de Moraes, VLG ;

Costa, SS .

PLANTA MEDICA, 2000, 66 (02) :134-137

[17]

Almeida C. C. S., 1997, ARQ MED ABC, V1-2, P7

[18] Bryophyllum pinnatum inhibits arginase II activity and prevents oxidative damage occasioned by carbon tetrachloride (CCl4) in rats [J].

Anadozie, Scholastica Onyebuchi ;

Akinyemi, Jacob Ayodele ;

Agunbiade, Shadrach ;

Ajiboye, Basiru Olaitan ;

Adewale, Olusola Bolaji .

BIOMEDICINE & PHARMACOTHERAPY, 2018, 101 :8-13

[19]

Anjoo Kamboj Anjoo Kamboj, 2009, Pharmacognosy Reviews, V3, P364

[20]

[Anonymous], 2005, COLETANEA CIENTIFICA

← 1 2 3 4 5 6 7 8 9 10 →