Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study

被引:62
作者
Cano, M. [1 ,2 ]
Martinez-Zalacain, I. [1 ]
Bernabeu-Sanz, A. [3 ]
Contreras-Rodriguez, O. [1 ,4 ]
Hernandez-Ribas, R. [1 ,2 ,4 ]
Via, E. [5 ]
de Arriba-Arnau, A. [1 ]
Galvez, V. [6 ,7 ]
Urretavizcaya, M. [1 ,2 ,4 ]
Pujol, J. [4 ,8 ]
Menchon, J. M. [1 ,2 ,4 ,10 ]
Cardoner, N. [5 ]
Soriano-Mas, C. [1 ,4 ,9 ]
机构
[1] Bellvitge Univ Hosp, Dept Psychiat, IDIBELL, Barcelona, Spain
[2] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain
[3] Inscanner SL, Magnet Resonance Dept, Alicante, Spain
[4] CIBERSAM, Carlos Hlth Inst 3, Madrid, Spain
[5] Univ Autonoma Barcelona, Mental Hlth Dept, Barcelona, Spain
[6] UNSW, Sch Psychiat, Sydney, NSW, Australia
[7] Black Dog Inst, Sydney, NSW, Australia
[8] Hosp Mar, Dept Radiol, MRI Res Unit, Barcelona, Spain
[9] Univ Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona, Spain
[10] Bellvitge Univ Hosp, Dept Psychiat, IDIBELL, Feixa Llarga S-N, Barcelona 08907, Spain
来源
TRANSLATIONAL PSYCHIATRY | 2017年 / 7卷
关键词
PROTON-MAGNETIC-RESONANCE; GRAY-MATTER VOLUME; HIPPOCAMPAL VOLUME; PREFRONTAL CORTEX; MAJOR DEPRESSION; PLASTICITY; ECT; NEUROGENESIS; SEIZURES; INCREASE;
D O I
10.1038/tp.2016.267
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Recent research suggests that neuroplastic and neuroinflammatory changes may account for the mode of action of electroconvulsive therapy (ECT), although extant data do not allow for a clear disambiguation between these two hypotheses. Multimodal neuroimaging approaches (for example, combining structural and metabolic information) may help in clarifying this issue. Here we aimed to assess longitudinal changes in (i) regional gray matter (GM) volumes and (ii) hippocampal metabolite concentrations throughout an acute course of bitemporal ECT, as well as (iii) to determine the association between imaging changes and clinical improvement. We assessed 12 patients with treatment-resistant depression (TRD) at four time points (pretreatment, after the first ECT session, after the ninth ECT session and 15 days after ECT course completion) and 10 healthy participants at two time points, 5 weeks apart. Patients with TRD showed bilateral medial temporal lobe (MTL) and perigenual anterior cingulate cortex volume increases. Left MTL volume increase was associated with (i) a hippocampal N-acetylaspartate concentration decrease, (ii) a hippocampal Glutamate+ Glutamine concentration increase and (iii) significant clinical improvement. The observed findings are, in part, compatible with both neuroplastic and neuroinflammatory changes induced by ECT. We postulate that such phenomena may be interrelated, therefore reconciling the neuroplasticity and neuroinflammatory hypotheses of ECT action.
引用
收藏
页码:e1023 / e1023
页数:8
相关论文
共 65 条
  • [1] Hippocampal structural and functional changes associated with electroconvulsive therapy response
    Abbott, C. C.
    Jones, T.
    Lemke, N. T.
    Gallegos, P.
    McClintock, S. M.
    Mayer, A. R.
    Bustillo, J.
    Calhoun, V. D.
    [J]. TRANSLATIONAL PSYCHIATRY, 2014, 4 : e483 - e483
  • [2] A Review of Longitudinal Electroconvulsive Therapy: Neuroimaging Investigations
    Abbott, Christopher C.
    Gallegos, Patrick
    Rediske, Nathan
    Lemke, Nicholas T.
    Quinn, Davin K.
    [J]. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 2014, 27 (01) : 33 - 46
  • [3] Imaging structural co-variance between human brain regions
    Alexander-Bloch, Aaron
    Giedd, Jay N.
    Bullmore, Edward T.
    [J]. NATURE REVIEWS NEUROSCIENCE, 2013, 14 (05) : 322 - 336
  • [4] Electroconvulsive Therapy, Hypertensive Surge, Blood-Brain Barrier Breach, and Amnesia Exploring the Evidence for a Connection
    Andrade, Chittaranjan
    Bolwig, Tom G.
    [J]. JOURNAL OF ECT, 2014, 30 (02) : 160 - 164
  • [5] [Anonymous], 2007, STRUCTURED CLIN INTE
  • [6] [Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787
  • [7] Unified segmentation
    Ashburner, J
    Friston, KJ
    [J]. NEUROIMAGE, 2005, 26 (03) : 839 - 851
  • [8] Ashburner J., 2007, FAST DIFFEOMORPHIC I
  • [9] Symmetric diffeomorphic modeling of longtudinal structural MRI
    Ashburner, John
    Ridgway, Gerard R.
    [J]. FRONTIERS IN NEUROSCIENCE, 2013, 6
  • [10] Diffeomorphic registration using geodesic shooting and Gauss-Newton optimisation
    Ashburner, John
    Friston, Karl J.
    [J]. NEUROIMAGE, 2011, 55 (03) : 954 - 967