Mitophagy: Basic Mechanism and Potential Role in Kidney Diseases

被引：46

作者：

Tang, Chengyuan ^{[1
]}

He, Liyu ^{[1
]}

Liu, Jing ^{[1
]}

Dong, Zheng ^{[1
,2
,3
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Hunan, Peoples R China

[2] Georgia Regents Univ, Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA USA

[3] Charlie Norwood VA Med Ctr, Augusta, GA USA

来源：

KIDNEY DISEASES | 2015年 / 1卷 / 01期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Kidney diseases; Mitochondria; Mitophagy; Cell death; MITOCHONDRIAL QUALITY-CONTROL; BCL-2 FAMILY PROTEINS; CELL-DEATH; DAMAGED MITOCHONDRIA; PARKINSONS-DISEASE; MEDIATED CLEAVAGE; TUBULAR CELLS; MITOFUSIN; AUTOPHAGY; INJURY;

D O I：

10.1159/000381510

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Mitochondria play fundamental roles in cellular metabolism, signaling, and viability. Disruption of mitochondria not only leads to dysfunction of the organelles but also activates mechanisms of cell injury and death, contributing to the pathogenesis of various diseases. Summary: Removal of damaged mitochondria is therefore crucial for cellular homeostasis and survival. Mitophagy, the selective elimination of mitochondria via autophagy, is an important mechanism of mitochondrial quality control in physiological and pathological conditions. Defects in mitophagy have been implicated in a variety of human disorders, including both acute and chronic kidney diseases. However, the role and regulatory mechanisms of mitophagy in kidney cells and tissues remain largely unknown. Key Message: This review provides updated information on mitophagy and suggests a potential role of mitophagy in renal pathophysiology. (C) 2015 S. Karger AG, Basel

引用

页码：71 / 79

页数：9

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