Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine

被引：48

作者：

Mueller, Ruediger B.

Sheriff, Ahmed

Gaipl, Udo S.

Wesselborg, Sebastian

Lauber, Kirsten

机构：

[1] Univ Hosp Erlangen, Inst Clin Immunol & Rheumatol, Dept Internal Med 3, D-91054 Erlangen, Germany

[2] Univ Tubingen, Dept Internal Med 1, D-72076 Tubingen, Germany

来源：

AUTOIMMUNITY | 2007年 / 40卷 / 04期

关键词：

apoptosis; attraction signal; caspase3; LPC;

D O I：

10.1080/08916930701356911

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptotic cells promote the phagocytosis of themselves via the exposure of "eat me" signals. Furthermore, a second, "find me" signal is required to attract phagocytes. In this review the double function of lysophosphatidylcholine for the clearence of apoptotic material as factor leading to attraction of phagocytes as a soluble "find me" signal and opsonisation of apoptotic cells as a membrane bound "eat me" signal is outlined. Lysophosphatidylcholine, exerting this bivalent function, leads to a sufficient clearance of apoptotic cell as a "keep calm" mechanism to prevent activation of the immune system by secondary necrosis.

引用

收藏

页码：342 / 344

页数：3

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