Should Undetectable Minimal Residual Disease Be the Goal of Chronic Lymphocytic Leukemia Therapy?

被引:9
作者
Al-Sawaf, Othman [1 ]
Seymour, John F. [2 ]
Kater, Arnon P. [3 ]
Fischer, Kirsten [1 ]
机构
[1] Univ Hosp, Dept Internal Med, Ctr Integrated Oncol Cologne Bonn, German CLL Study Grp, Gleueler Str 176, D-50935 Cologne, Germany
[2] Univ Melbourne, Dept Hematol, Peter MacCallum Canc Ctr, Royal Melbourne Hosp, 305 Grattan St, Melbourne, Vic 3000, Australia
[3] Univ Amsterdam, Dept Hematol, Canc Ctr Amsterdam, Lymphoma & Myeloma Res Ctr Amsterdam LYMMCARE,Ams, Amsterdam, Netherlands
关键词
MRD; Minimal residual disease; CLL; Chronic lymphocytic leukemia; Targeted agents; Chemoimmunotherapy; Fixed-duration therapy; PREVIOUSLY UNTREATED PATIENTS; OPEN-LABEL; FOLLOW-UP; 1ST-LINE TREATMENT; FLOW-CYTOMETRY; INDEPENDENT PREDICTOR; CELL TRANSPLANTATION; PLUS CHLORAMBUCIL; CLL; RITUXIMAB;
D O I
10.1016/j.hoc.2021.03.007
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hospital, German CLL Study Group, Gleueler Strasse 176, 50935 Cologne, Germany; b Department of Hematology, Peter MacCallum Cancer Centre, Royal Melbourne Hospital, University of Melbourne, 305 Grattan Street, Melbourne, Victoria 3000, Australia; cDepartment of Hematology, Cancer Center Amsterdam, Lymphoma and Myeloma Research Center Amsterdam (LYMMCARE), Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands * Corresponding author. Department of Hematology, D3-221.1, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, Amsterdam 1105AZ, the Netherlands.
引用
收藏
页码:775 / 791
页数:17
相关论文
共 81 条
[1]   Depth and durability of response to ibrutinib in CLL: 5-year follow-up of a phase 2 study [J].
Ahn, Inhye E. ;
Farooqui, Mohammed Z. H. ;
Tian, Xin ;
Valdez, Janet ;
Sun, Clare ;
Soto, Susan ;
Lotter, Jennifer ;
Housel, Stephanie ;
Stetler-Stevenson, Maryalice ;
Yuan, Constance M. ;
Maric, Irina ;
Calvo, Katherine R. ;
Nierman, Pia ;
Hughes, Thomas E. ;
Saba, Nakhle S. ;
Marti, Gerald E. ;
Pittaluga, Stefania ;
Herman, Sarah E. M. ;
Niemann, Carsten U. ;
Pedersen, Lone B. ;
Geisler, Christian H. ;
Childs, Richard ;
Aue, Georg ;
Wiestner, Adrian .
BLOOD, 2018, 131 (21) :2357-2366
[2]  
Al-Sawaf O, 2020, LANCET ONCOL, V21, P1188, DOI 10.1016/S1470-2045(20)30443-5
[3]   High efficacy of venetoclax plus obinutuzumab in patients with complex karyotype and chronic lymphocytic leukemia [J].
Al-Sawaf, Othman ;
Lilienweiss, Esther ;
Bahlo, Jasmin ;
Robrecht, Sandra ;
Fink, Anna-Maria ;
Patz, Michaela ;
Tandon, Maneesh ;
Jiang, Yanwen ;
Schary, William ;
Ritgen, Matthias ;
Tausch, Eugen ;
Stilgenbauer, Stephan ;
Eichhorst, Barbara ;
Fischer, Kirsten ;
Hallek, Michael ;
Kreuzer, Karl-Anton .
BLOOD, 2020, 135 (11) :866-870
[4]   Standardized MRD flow and ASO IGH RQ-PCR for MRD quantification in CLL patients after rituximab-containing immunochemotherapy: a comparative analysis [J].
Boettcher, S. ;
Stilgenbauer, S. ;
Busch, R. ;
Brueggemann, M. ;
Raff, T. ;
Pott, C. ;
Fischer, K. ;
Fingerle-Rowson, G. ;
Doehner, H. ;
Hallek, M. ;
Kneba, M. ;
Ritgen, M. .
LEUKEMIA, 2009, 23 (11) :2007-2017
[5]   The Role of Minimal Residual Disease Measurements in the Therapy for CLL Is It Ready for Prime Time? [J].
Boettcher, Sebastian ;
Hallek, Michael ;
Ritgen, Matthias ;
Kneba, Michael .
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2013, 27 (02) :267-+
[6]   Minimal Residual Disease Quantification Is an Independent Predictor of Progression-Free and Overall Survival in Chronic Lymphocytic Leukemia: A Multivariate Analysis From the Randomized GCLLSG CLL8 Trial [J].
Boettcher, Sebastian ;
Ritgen, Matthias ;
Fischer, Kirsten ;
Stilgenbauer, Stephan ;
Busch, Raymonde M. ;
Fingerle-Rowson, Guenter ;
Fink, Anna Maria ;
Buehler, Andreas ;
Zenz, Thorsten ;
Wenger, Michael Karl ;
Mendila, Myriam ;
Wendtner, Clemens-Martin ;
Eichhorst, Barbara F. ;
Doehner, Hartmut ;
Hallek, Michael J. ;
Kneba, Michael .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (09) :980-988
[7]   Allogeneic stem cell transplantation for chronic lymphocytic leukemia: Lessons to be learned from minimal residual disease studies [J].
Boettcher, Sebastian ;
Ritgen, Matthias ;
Dreger, Peter .
BLOOD REVIEWS, 2011, 25 (02) :91-96
[8]   Comparative analysis of minimal residual disease detection using four-color flow cytometry, consensus IgH-PCR, and quantitative IgH PCR in CLL after allogeneic and autologous stem cell transplantation [J].
Böttcher, S ;
Ritgen, M ;
Pott, C ;
Brüggemann, M ;
Raff, T ;
Stilgenbauer, S ;
Döhner, H ;
Dreger, P ;
Kneba, M .
LEUKEMIA, 2004, 18 (10) :1637-1645
[9]   Durability of Responses on Continuous Therapy and Following Drug Cessation with Venetoclax and Rituximab: Long-Term Follow-up Analysis of a Phase 1b Study in Patients with Relapsed CLL [J].
Brander, Danielle M. ;
Seymour, John F. ;
Kipps, Thomas J. ;
Ma, Shuo ;
Anderson, Mary Ann ;
Choi, Michael Y. ;
Humphrey, Kathryn ;
Al Masud, Abdullah ;
Nandam, Ruby ;
Jacobson, Amanda ;
Roberts, Andrew W. .
BLOOD, 2019, 134
[10]   Circulating cell-free DNA in hematological malignancies [J].
Buedts, Lieselot ;
Vandenberghe, Peter .
HAEMATOLOGICA, 2016, 101 (09) :997-999