Anti-diabetic effect of methylswertianin and bellidifolin from Swertia punicea Hemsl. and its potential mechanism

被引:44
|
作者
Tian, L. -Y. [1 ]
Bai, X. [1 ]
Chen, X. -H. [1 ]
Fang, J. -B. [1 ]
Liu, S. -H. [1 ]
Chen, J. -C. [1 ]
机构
[1] Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Tongji Sch Pharmaceut Sci, Wuhan 430030, Peoples R China
关键词
Swertia punicea Hemsl; Hypoglycemic; Methylswertianin; Bellidifolin; Insulin resistance; Insulin signaling; DIABETES-MELLITUS; INSULIN; GLUCOSE; HEXOKINASE; SWERCHIRIN; CHIRAYITA; EXTRACT; LIVER; RATS; MICE;
D O I
10.1016/j.phymed.2009.10.007
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
In this study, we continued to investigate the hypoglycemic activity of Swertia punicea Helmsl., the hypoglycemic and hypolipidemic effects of methylswertianin and bellidifolin from the active ethyl acetate (EtOAc) fraction, and the potential mechanism(s) underlying the improvement of insulin resistance. Streptozotocin (STZ)-induced type 2 diabetic male BABL/c mice treated with methylswertianin and bellidifolin at different doses (orally, 200 and 100 mg/kg body wt./day) for 4 weeks were analyzed in comparison to untreated mice. The results proved that methylswertianin and bellidifolin significantly reduced fasting blood glucose (FBG). The administration of both compounds also improved the oral glucose tolerance and lowered fasting serum insulin (FINS). Moreover, post-administration evaluation revealed lower serum total cholesterol (TC), low density lipoprotein cholesterol (LDL) and triglyceride (TG) levels and increased relative high density lipoprotein cholesterol (HDL) concentrations (HDL/TC). Methylswertianin and bellidifolin appeared to improve insulin resistance by enhancing insulin signaling. The expression levels of insulin-receptor a subunit (InsR-alpha), insulin-receptor substrate-1 (IRS-1), and phosphatidylinositol 3-kinase (PI3K) were also increased after administration. Meanwhile, methylswertianin and bellidifolin increased hepatic glycogen content, decreased glucokinase (GK) activities and increased glucose-6-phosphatase (G6Pase) activities. In conclusion, these result indicated that methylswertianin and bellidifolin could be useful for treating type-2 diabetes, likely via the improvement of insulin resistance (IR). Crown Copyright (C) 2009 Published by Elsevier GmbH. All rights reserved.
引用
收藏
页码:533 / 539
页数:7
相关论文
共 50 条
  • [21] Anti-diabetic Effect of Major Compounds from Commelina diffusa
    Vu, Duc Loi
    Nguyen, Thi Van Anh
    Nguyen, Tien Dat
    Dang, Viet Hau
    Le, Hong Duong
    Nguyen, Xuan Tung
    REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2023, 33 (03): : 657 - 661
  • [22] Anti-diabetic Effect of Major Compounds from Commelina diffusa
    Duc Loi Vu
    Thi Van Anh Nguyen
    Tien Dat Nguyen
    Viet Hau Dang
    Hong Duong Le
    Xuan Tung Nguyen
    Revista Brasileira de Farmacognosia, 2023, 33 : 657 - 661
  • [23] Anti-inflammatory and Anti-diabetic Potential of Echinoderm Species from Mindanao, Philippines
    Gelani, C.
    La Villa, C.
    Duhaylungsod, G. L.
    Indanao, R. J.
    Labrador, Q.
    Mamalo, M.
    Masorong, A.
    Monte de Ramos, A.
    Rafanan, C., I
    PLANTA MEDICA, 2022, 88 (15) : 1504 - 1505
  • [24] POTENTIATION OF INSULIN ACTION - PROBABLE MECHANISM FOR ANTI-DIABETIC EFFECT OF SULFONYLUREA DRUGS
    FEINGLOS, MN
    BUCHOLTZ, HK
    LEBOVITZ, HE
    CLINICAL RESEARCH, 1977, 25 (03): : A390 - A390
  • [25] Anti-diabetic effect of citrus pectin in diabetic rats and potential mechanism via PI3K/Akt signaling pathway
    Liu, Yanlong
    Dong, Man
    Yang, Ziyu
    Pan, Siyi
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 89 : 484 - 488
  • [26] Anti-diabetic Properties of Chrysophanol and Its Glucoside from Rhubarb Rhizome
    Lee, Myung Sun
    Sohn, Cheon Bae
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (11) : 2154 - 2157
  • [27] EFFECT OF SUBSTITUENTS ON POLAROGRAPHIC-REDUCTION OF SOME POTENTIAL ANTI-DIABETIC ARYLAZOTHIADIAZINES
    JAIN, R
    MALIK, WU
    INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1983, 22 (04): : 331 - 332
  • [28] Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis
    Zhou, Ping
    Xie, Weijie
    He, Shuaibing
    Sun, Yifan
    Meng, Xiangbao
    Sun, Guibo
    Sun, Xiaobo
    CELLS, 2019, 8 (03)
  • [30] Anti-diabetic mechanism and potential bioactive peptides of casein hydrolysates in STZ/HFD-induced diabetic rats
    Wang, Chenyang
    Luo, Donghui
    Zheng, Lin
    Zhao, Mouming
    JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2024, 104 (05) : 2947 - 2958