Transdermal drug delivery: 30+years of war and still fighting!

被引:202
作者
Wiedersberg, Sandra [1 ]
Guy, Richard H. [2 ]
机构
[1] LTS Lohmann Therapie Syst AG, D-56626 Andernach, Germany
[2] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 4LZ, Avon, England
关键词
Transdermal drug delivery; Skin barrier function; Controlled release; VACCINE DELIVERY; SKIN; PERMEABILITY; TECHNOLOGIES; MICRONEEDLES; PROSPECTS; PEPTIDES; PROTEINS;
D O I
10.1016/j.jconrel.2014.05.022
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
By any measure, transdermal drug delivery (TDD) is a successful controlled release technology. Over the last 30+ years, a steady flux of transdermal products have received regulatory approval and reached the market. For the right compounds, TDD is an effective and preferred route of administration; for others, delivery across the skin makes no sense at all. Currently, the "rules" that govern (passive) TDD feasibility are clearly understood, and research activity is focused on novel approaches that strive to subvert skin's excellent barrier function, and broaden the range of active species amenable to percutaneous administration. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:150 / 156
页数:7
相关论文
共 21 条
[1]  
Cleary G., 1993, TOPICAL DRUG BIOAVAI, P17, DOI DOI 10.1007/978-1-4899-1262-6_2
[2]   A NEW METHOD FOR ESTIMATING DERMAL ABSORPTION FROM CHEMICAL-EXPOSURE .1. GENERAL-APPROACH [J].
CLEEK, RL ;
BUNGE, AL .
PHARMACEUTICAL RESEARCH, 1993, 10 (04) :497-506
[3]  
Delgado M.B., 2001, Drug delivery and targeting, P207
[4]   Non-invasive iontophoretic delivery of peptides and proteins across the skin [J].
Gratieri, Tais ;
Kalaria, Dhaval ;
Kalia, Yogeshvar N. .
EXPERT OPINION ON DRUG DELIVERY, 2011, 8 (05) :645-663
[5]   RATE CONTROL IN TRANSDERMAL DRUG DELIVERY [J].
GUY, RH ;
HADGRAFT, J .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1992, 82 (03) :R1-R6
[6]  
Guy Richard H, 2010, Handb Exp Pharmacol, P399, DOI 10.1007/978-3-642-00477-3_13
[7]   Predicting the Rate and Extent of Fragrance Chemical Absorption into and through the Skin [J].
Guy, Richard H. .
CHEMICAL RESEARCH IN TOXICOLOGY, 2010, 23 (05) :864-870
[8]  
Hadgraft J, 2003, DRUGS PHARM SCI, V123, P1
[9]  
Hadgraft J., 2006, American Journal of Drug Delivery, V4, P153, DOI DOI 10.2165/00137696-200604030-00003
[10]   Microneedles for drug and vaccine delivery [J].
Kim, Yeu-Chun ;
Park, Jung-Hwan ;
Prausnitz, Mark R. .
ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 (14) :1547-1568