The effects of single dose of methamphetamine on lipid peroxidation levels in the rat striatum and prefrontal cortex

被引：31

作者：

Açikgöz, O ^{[1
]}

Gönenç, S

Kayatekin, BM

Pekçtin, C

Uysal, N

Dayi, A

Semin, I

Güre, A

机构：

[1] Dokuz Eylul Univ, Sch Med, Dept Physiol, TR-35340 Izmir, Turkey

[2] Dokuz Eylul Univ, Sch Med, Dept Histol & Embryol, TR-35340 Izmir, Turkey

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2000年 / 10卷 / 05期

关键词：

dopamine; methamphetamine; oxidative stress; lipid peroxidation; striatum; prefrontal cortex;

D O I：

10.1016/S0924-977X(00)00103-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The administration of methamphetamine to experimental animals results in damage to dopaminergic neurons. In the present study, we demonstrated that a single dose (15 mg/kg) of methamphetamine results in production of oxidative stress as demonstrated by increased thiobarbituric acid reactive substances levels in the rat striatum and prefrontal cortex. In conclusion, the results of present study provide further evidence in support of the notion that oxidative stress may play an important role in the methamphetamine-induced neurotoxicity. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：415 / 418

页数：4

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