Calcitonin Gene-Related Peptide (CGRP) Antagonists and Their Use in Migraines

被引：7
|
作者：
Henson, Brianna [1 ]
Hollingsworth, Hanna [2 ]
Nevois, Erika [3 ]
Herndon, Chris [4 ]
机构：
[1] Wake Forest Baptist Hlth Brenner Childrens Hosp, Winston Salem, NC USA
[2] Parkland Hlth & Hosp Syst, Dallas, TX USA
[3] CVS Pharm, Springfield, IL USA
[4] Southern Illinois Univ Edwardsville, Sch Pharm, 200 Univ Pk Dr, Edwardsville, IL 62026 USA
来源：
JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY | 2020年 / 34卷 / 01期
关键词：
CGRP; migraine; calcitonin gene-related peptide; erenumab; galcanezumab; fremanezumab; DOUBLE-BLIND; EPISODIC MIGRAINE; RECEPTOR ANTAGONISTS; PREVENTIVE TREATMENT; EFFICACY; SAFETY; ANTIBODY; PHASE-2; TRIAL;
D O I：
10.1080/15360288.2019.1690616
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Migraine is highly prevalent and associated with a large socio-economic burden in the United States. Current preventive medications have variable efficacy and their use is often limited by intolerable side effects. Calcitonin gene-related peptide (CGRP) has been identified as an integral part of migraine pathophysiology. There are currently seven CGRP antagonists under investigation, all of which are undergoing or have completed phase 3 clinical trials. Three of the investigated CGRP antagonists are approved for use within and outside of the United States. The trials have resulted in positive efficacy and safety data. The purpose of this review is to evaluate the seven CGRP antagonists and their future place in therapy.
引用
收藏
页码：22 / 31
页数：10
相关论文
共 50 条
  • [11] Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists
    Mercer, Stephen E.
    Chaturvedula, Prasad V.
    Conway, Charles M.
    Cook, Deborah A.
    Davis, Carl D.
    Pin, Sokhom S.
    Macci, Robert
    Schartman, Richard
    Signor, Laura J.
    Widmann, Kimberly A.
    Whiterock, Valerie J.
    Chen, Ping
    Xu, Cen
    Herbst, John J.
    Kostich, Walter A.
    Thalody, George
    Macor, John E.
    Dubowchik, Gene M.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 31
  • [12] Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine
    Brain, SD
    BRITISH JOURNAL OF PHARMACOLOGY, 2004, 142 (07) : 1053 - 1054
  • [13] Calcitonin gene-related peptide (CGRP) receptor antagonists: Investigations of a pyridinone template
    Nguyen, Diem N.
    Paone, Daniel V.
    Shaw, Anthony W.
    Burgey, Christopher S.
    Mosser, Scott D.
    Johnston, Victor
    Salvatore, Christopher A.
    Leonard, Yvonne M.
    Miller-Stein, Cynthia M.
    Kane, Stefanie A.
    Koblan, Kenneth S.
    Vacca, Joseph P.
    Graham, Samuel L.
    Williams, Theresa M.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (02) : 755 - 758
  • [14] Anti-Calcitonin Gene-Related Peptide (CGRP) Therapies: Update on a Previous Review After the American Headache Society 60th Scientific Meeting, San Francisco, June 2018
    Tepper, Stewart J.
    HEADACHE, 2018, 58 : 276 - 290
  • [15] Calcitonin Gene-Related Peptide Antagonists for the Prevention of Migraine: Highlights From Pivotal Studies and the Clinical Relevance of This New Drug Class
    Arca, Karissa
    Reynolds, Jenna
    Sands, Kara A.
    Shiue, Harn J.
    ANNALS OF PHARMACOTHERAPY, 2020, 54 (08) : 795 - 803
  • [16] Update on Calcitonin Gene-Related Peptide Antagonism in the Treatment of Migraine
    Caronna, Edoardo
    Starling, Amaal J.
    NEUROLOGIC CLINICS, 2021, 39 (01) : 1 - 19
  • [17] Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead
    Luo, Guanglin
    Jiang, Xiang-Jun
    Chen, Ling
    Conway, Charles M.
    Gulianello, Michael
    Kostich, Walter
    Keavy, Deborah
    Signor, Laura J.
    Chen, Ping
    Davis, Carl
    Whiterock, Valerie J.
    Schartman, Richard
    Widmann, Kimberly A.
    Macor, John E.
    Dubowchik, Gene M.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 43
  • [18] Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines
    Burgey, Christopher S.
    Potteiger, Craig M.
    Deng, James Z.
    Mosser, Scott D.
    Salvatore, Christopher A.
    Yu, Sean
    Roller, Shane
    Kane, Stefanie A.
    Vacca, Joseph P.
    Williams, Theresa M.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (22) : 6368 - 6372
  • [19] Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine
    Durham P.L.
    Vause C.V.
    CNS Drugs, 2010, 24 (7) : 539 - 548
  • [20] Efficacy and Safety of Anti-calcitonin Gene-Related Peptide (CGRP) Monoclonal Antibodies in Preventing Migraines: A Systematic Review
    Muddam, Meghana Reddy
    Obajeun, Omobolanle A.
    Abaza, Abdelrahman
    Jaramillo, Arturo P.
    Idris, Faten Sid
    Shaikh, Humna Anis
    Vahora, Ilma
    Moparthi, Kiran Prasad
    Rushaidi, Majdah T. Al
    Nath, Tuheen Sankar
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (09)
12345