The role of KIR positive NK cells in diseases and its importance in clinical intervention

被引：25

作者：

Asl, Khadijeh Dizaji ^{[1
,2
]}

Velaei, Kobra ^{[2
]}

Rafat, Ali ^{[1
,2
]}

Nasrabadi, Hamid Tayefi ^{[2
]}

Movassaghpour, Ali Akbar ^{[3
]}

Mahdavi, Majid ^{[4
]}

Charoudeh, Hojjatollah Nozad ^{[1
]}

机构：

[1] Tabriz Univ Med Sci, Stem Cell Res Ctr, Imam Reza St,Golgasht St, Tabriz 5166614756, Iran

[2] Tabriz Univ Med Sci, Fac Med, Dept Anat Sci, Tabriz, Iran

[3] Tabriz Univ Med Sci, Hematol & Oncol Res Ctr, Tabriz, Iran

[4] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz, Iran

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2021年 / 92卷

关键词：

Natural killer cells; Killer cell immunoglobulin-like receptors; MHC class I; Hematological malignancies; Autoimmune diseases; NATURAL-KILLER-CELLS; IMMUNOGLOBULIN-LIKE RECEPTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CLASS-I MOLECULES; CORD BLOOD TRANSPLANTATION; T-CELL; MULTIPLE-SCLEROSIS; HLA-G; HUMAN CYTOTROPHOBLASTS; INHIBITORY RECEPTORS;

D O I：

10.1016/j.intimp.2020.107361

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are essential for the elimination of the transformed and cancerous cells. Killer cell immunoglobulin-like receptors (KIRs) which expressed by T and NK cells, are key regulator of NK cell function. The KIR and their ligands, MHC class I (HLA-A, B and C) molecules, are highly polymorphic and their related genes are located on 19 q13.4 and 6 q21.3 chromosomes, respectively. It is clear that particular interaction between the KIRs and their related ligands can influence on the prevalence, progression and outcome of several diseases, like complications of pregnancy, viral infection, autoimmune diseases, and hematological malignancies. The mechanisms of immune signaling in particular NK cells involvement in causing pathological conditions are not completely understood yet. Therefore, better understanding of the molecular mechanism of KIR-MHC class I interaction could facilitate the treatment strategy of diseases. The present review focused on the main characteristics and functional details of various KIR and their combination with related ligands in diseases and also highlights ongoing efforts to manipulate the key checkpoints in NK cell-based immunotherapy.

引用

页数：12

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