A new cytotoxic tambjamine alkaloid from the Azorean nudibranch Tambja ceutae

被引：42

作者：

Carbone, Marianna ^{[1
]}

Irace, Carlo ^{[2
]}

Costagliola, Francesca ^{[1
]}

Castelluccio, Francesco ^{[1
]}

Villani, Guido ^{[1
]}

Calado, Goncalo ^{[3
]}

Padula, Vinicius ^{[4
]}

Cimino, Guido ^{[1
]}

Cervera, J. Lucas ^{[5
]}

Santamaria, Rita ^{[2
]}

Gavagnin, Margherita ^{[1
]}

机构：

[1] CNR, Ist Chim Biomol, I-80078 Pozzuoli, Na, Italy

[2] Univ Naples Federico 2, Fac Farm, Dipartimento Farmacol Sperimentale, Naples, Italy

[3] Univ Lusofona Humanidades & Tecnol, P-1749024 Lisbon, Portugal

[4] Univ Fed Rio de Janeiro, Dept Invertebrados, Museo Nacl, BR-20940040 Rio De Janeiro, Brazil

[5] Univ Cadiz, Dept Biol, Fac Ciencias Mar & Ambientales, Cadiz 11510, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 08期

关键词：

Marine natural products; Bromopyrrole alkaloids; Spectroscopic methods; Cytotoxic activity; MARINE OPISTHOBRANCH MOLLUSKS; BRYOZOAN BUGULA-DENTATA; METABOLITES; BE-18591; PIGMENT;

D O I：

10.1016/j.bmcl.2010.02.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The chemical investigation of Azorean nudibranch mollusk Tambja ceutae led us to isolate a new member of the tambjamine family, tambjamine K (1). The bryozoan Bugula dentata, prey of the nudibranch, was also analyzed and found to contain compound 1 in very small amounts together with known blue pigment 2 and tambjamines A (3) and B (4). The structure of tambjamine 1 was elucidated by the interpretation of the spectroscopic data as well as by the comparison with related compounds. Compounds 1 and 2 possess antiproliferative activity, in particular, tambjamine K (1) displayed high cytotoxicity against both tumor and non-tumor mammalian cells. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2668 / 2670

页数：3

共 18 条

[1] NEW TAMBJAMINE ALKALOIDS FROM THE MARINE BRYOZOAN BUGULA-DENTATA [J].