Multiple basal cell carcinomas and malignant melanoma following radiotherapy for ankylosing spondylitis

被引：11

作者：

Beswick, SJ ^{[1
]}

Garrido, MC

Fryer, AA

Strange, RC

Smith, AG

机构：

[1] N Staffordshire Hosp, Postgrad Med Sch, Dept Dermatol, Stoke On Trent ST4 7PA, Staffs, England

[2] N Staffordshire Hosp, Postgrad Med Sch, Dept Histopathol, Stoke On Trent ST4 7PA, Staffs, England

[3] N Staffordshire Hosp, Postgrad Med Sch, Ctr Cell & Mol Med, Stoke On Trent ST4 7PA, Staffs, England

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2000年 / 25卷 / 05期

关键词：

D O I：

10.1046/j.1365-2230.2000.00668.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We present the case of a 53-year-old Caucasian woman with seven basal cell carcinomas and one malignant melanoma in situ along her back overlying her spine, which was irradiated in 1968 for ankylosing spondylitis. These lesions developed between 1997 and 1999. She has no other known risk factors for cutaneous malignancy, in particular no history of excessive sun exposure. She has skin type 2. Molecular studies of glutathione S-transferase and cytochrome P450 status showed her genotype not to constitute an overall increased inherited susceptibility. We therefore postulate that all her skin cancers have arisen as a consequence of her radiotherapy. To our knowledge this is the first case of multiple basal cell carcinoma in addition to a malignant melanoma following radiotherapy for benign disease.

引用

页码：381 / 383

页数：3

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