Clubbed thiazoles by MAOS: A novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer's disease

被引：57

作者：

Shiradkar, Mahendra Ramesh

Akula, Kalyan Chakravarthy

Dasari, Varaprasad

Baru, Vijayakumar

Chiningiri, Bhoomeshwar

Gandhi, Santosh

Kaur, Ranjit

机构：

[1] Dr Reddys Labs, Andhra Pradesh, India

[2] CKM PG Coll, Med Chem Lab, Warangal 500001, Andhra Pradesh, India

[3] LB Nagar, Sai Life Sci, Hyderabad, Andhra Pradesh, India

[4] AISSMS, Coll Pharm, Pune 411001, Maharashtra, India

[5] St Johns Coll Pharm, Bangalore 560040, Karnataka, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 07期

关键词：

thiazole; triazole; cdk5/p25; Alzheimer's disease;

D O I：

10.1016/j.bmc.2007.01.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2601 / 2610

页数：10

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