Acute Chagas Disease Caused by Trypanosoma cruzi TcIV and Transmitted by Panstrongylus geniculatus: Molecular Epidemiological Insights Provided by the First Documented Autochthonous Case in Rondonia, Southwestern Amazonia, Brazil

被引：3

作者：

Juliao, Genimar Reboucas ^{[1
,2
]}

Braganca, Mariana Ayres Henrique ^{[3
]}

Torres, Patricia Guedes ^{[3
]}

Lima, Luciana ^{[2
]}

Neves, Rosenilton de Araujo ^{[5
]}

Nobre, Jose Maria Silva ^{[5
]}

Vergara-Meza, Jose Gabriel ^{[2
,4
]}

Basano, Sergio de Almeida ^{[3
,6
]}

Moraes, Francielle Alba ^{[3
]}

Baldez, Maria Arlete da Gama ^{[5
]}

Tada, Mauro Shugiro ^{[2
,7
,8
]}

de Lima, Alzemar Alves ^{[6
,7
]}

Costa, Joana D'Arc Neves ^{[5
,7
]}

Gil, Luiz Herman Soares ^{[8
]}

da Cunha, Alda E. F. Lobato ^{[9
]}

Camargo, Erney Plessmann ^{[2
,4
]}

Teixeira, Marta Maria Geraldes ^{[2
,4
]}

机构：

[1] Fundacao Oswaldo Cruz, Fiocruz Rondonia, Lab Entomol 1, Rua Beira 7671, BR-76812245 Porto Velho, Rondonia, Brazil

[2] Fiocruz Rondonia, Inst Nacl Epidemiol Amazonia Ocidental INCT EpiAm, Porto Velho, Brazil

[3] Ctr Med Trop Rondonia, Porto Velho, Brazil

[4] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo, Brazil

[5] Agencia Estadual Vigilancia Saude Rondonia, Porto Velho, Brazil

[6] Ctr Univ Sao Lucas, Porto Velho, Brazil

[7] Ctr Pesquisa Med Trop Rondonia, Porto Velho, Brazil

[8] Inst Pesquisa Patol Trop Rondonia, Porto Velho, Brazil

[9] Lab Cent Saude Publ Rondonia, Porto Velho, Brazil

来源：

VECTOR-BORNE AND ZOONOTIC DISEASES | 2022年 / 22卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

DTUs TcIV and TcIII; molecular diagnosis; forest triatomines; ORAL-TRANSMISSION; STATE; IDENTIFICATION; SURVEILLANCE; TRIATOMINES; REDUVIIDAE; BASIN; MUNICIPALITY; ENDEMICITY; MORBIDITY;

D O I：

10.1089/vbz.2021.0086

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Recurrent outbreaks of oral infection and isolated cases characterize the new epidemiological scenario of Chagas disease (CD) in the Brazilian Amazon. Acute Chagas disease (ACD) is common in Para and Amazonas, Northeastern and Northwestern Brazilian Amazonia. In the present study, we describe the first molecularly characterized autochthonous case of ACD in Rondonia, Southwestern Amazonia. The patient, a 39-year-old male resident in the small city of Cujubim, presented typical ACD symptoms: fever, asthenia, myalgia, progressive dyspnea, swelling of the legs, and tiredness at minimal efforts, all compatible with ACD and indicative of cardiac involvement. A thick blood drop test revealed trypomastigote forms of Trypanosoma cruzi genotyped as TcIV. An epidemiological investigation ruled out oral infection, and support for vectorial transmission included the finding of Panstrongylus geniculatus positive for T. cruzi (TcIII and TcIV) inside the tent used by the patient when harvesting forest timber, and a circular cutaneous lesion resembling a chagoma of inoculation. Treatment with benznidazole led to blood parasite clearance as confirmed by molecular tests. Altogether, our findings fitted well into the ecological scenario where deforestation and colonization of forested areas represent an important risk factor to the adaptation of P. geniculatus to human habitats, favoring vectorial transmission of CD in the Amazonian region.

引用

页码：244 / 251

页数：8