Mansouramycins A-D, Cytotoxic Isoquinolinequinones from a Marine Streptomycete

被引：84

作者：

Hawas, Usama W. ^{[1
]}

Shaaban, Mohamed ^{[1
]}

Shaaban, Khaled A. ^{[1
]}

Speitling, Michael ^{[1
]}

Maier, Armin ^{[2
]}

Kelter, Gerhard ^{[2
]}

Fiebig, Heinz H. ^{[2
]}

Meiners, Marinus ^{[3
]}

Helmke, Elisabeth ^{[4
]}

Laatsch, Hartmut ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Oncotest GmbH, D-79108 Freiburg, Germany

[3] Fachhsch Ostfriesland, D-26726 Emden, Germany

[4] Alfred Wegener Inst Polar & Marine Res, D-27570 Bremerhaven, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 12期

关键词：

METABOLITES; QUINONES; CRIBROCHALINA; ANTIBIOTICS; LAVENDULAE; MIMOCIN; ASSAY;

D O I：

10.1021/np900160g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)-5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.

引用

页码：2120 / 2124

页数：5

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